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10.1016/j.virol.2021.07.012 http://scihub22266oqcxt.onion/10.1016/j.virol.2021.07.012 34325286!8299723!34325286     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2021 ; 562 (ä): 142-148 Nephropedia Template TP {{tp|p=34325286|t=2021. SARS-CoV-2 and other coronaviruses bind to phosphorylated glycans from the human lung |pdf=|usr=}}{{34325286}} gab.com Text SARS-CoV-2 and other coronaviruses bind to phosphorylated glycans from the human lung JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=34325286 #FOAvip SARS-CoV, MERS-CoV, and potentially SARS-CoV-2 emerged as novel human coronaviruses following cross-species transmission from animal hosts. Although the receptor binding characteristics of human coronaviruses are well documented, the role of carbohydrate binding in addition to recognition of proteinaceous receptors has not been fully explored. Using natural glycan microarray technology, we identified N-glycans in the human lung that are recognized by various human and animal coronaviruses. All viruses tested, including SARS-CoV-2, bound strongly to a range of phosphorylated, high mannose N-glycans and to a very specific set of sialylated structures. Examination of two linked strains, human CoV OC43 and bovine CoV Mebus, reveals shared binding to the sialic acid form Neu5Gc (not found in humans), supporting the evidence for cross-species transmission of the bovine strain. Our findings, revealing robust recognition of lung glycans, suggest that these receptors could play a role in the initial stages of coronavirus attachment and entry. Twit Text FOAVip SARS-CoV-2 and other coronaviruses bind to phosphorylated glycans from the human lung ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=34325286 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34325286 #FOAvip English Wikipedia <ref>{{Cite pmid|34325286}}</ref> SARS-CoV-2 and other coronaviruses bind to phosphorylated glycans from the human lung #MMPMID34325286 Byrd-Leotis L; Lasanajak Y; Bowen T; Baker K; Song X; Suthar MS; Cummings RD; Steinhauer DA Virology 2021[Oct]; 562 (ä): 142-148 PMID34325286show ga SARS-CoV, MERS-CoV, and potentially SARS-CoV-2 emerged as novel human coronaviruses following cross-species transmission from animal hosts. Although the receptor binding characteristics of human coronaviruses are well documented, the role of carbohydrate binding in addition to recognition of proteinaceous receptors has not been fully explored. Using natural glycan microarray technology, we identified N-glycans in the human lung that are recognized by various human and animal coronaviruses. All viruses tested, including SARS-CoV-2, bound strongly to a range of phosphorylated, high mannose N-glycans and to a very specific set of sialylated structures. Examination of two linked strains, human CoV OC43 and bovine CoV Mebus, reveals shared binding to the sialic acid form Neu5Gc (not found in humans), supporting the evidence for cross-species transmission of the bovine strain. Our findings, revealing robust recognition of lung glycans, suggest that these receptors could play a role in the initial stages of coronavirus attachment and entry. |Animals[MESH] |COVID-19/*virology[MESH] |Cattle[MESH] |Host Microbial Interactions/*physiology[MESH] |Humans[MESH] |Lung/metabolism[MESH] |Mannose/chemistry[MESH] |Middle East Respiratory Syndrome Coronavirus/*metabolism/physiology[MESH] |N-Acetylneuraminic Acid/chemistry[MESH] |Phosphorylation[MESH] |Polysaccharides/*metabolism[MESH] |Protein Array Analysis[MESH] |Protein Binding[MESH] |SARS-CoV-2/*metabolism/physiology[MESH]SARS-CoV-2 and other coronaviruses bind to phosphorylated glycans from(epmc).pdf DeepDyve Pubget Overpricing