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10.1111/tid.13705

http://scihub22266oqcxt.onion/10.1111/tid.13705
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34324256!8420394!34324256
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suck abstract from ncbi


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pmid34324256      Transpl+Infect+Dis 2021 ; 23 (5): e13705
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  • Clinical effectiveness of COVID-19 vaccination in solid organ transplant recipients #MMPMID34324256
  • Aslam S; Adler E; Mekeel K; Little SJ
  • Transpl Infect Dis 2021[Oct]; 23 (5): e13705 PMID34324256show ga
  • GOAL: We aimed to assess the incidence rate of coronavirus disease 2019 (COVID-19) in vaccinated versus unvaccinated solid organ transplant recipients (SOTR) at our center. METHODS: We abstracted the following clinical data from our transplant registry from 1/1/2021 to 6/2/2021: demographics, details of COVID-19 vaccination, incidence of COVID-19, and related mortality. We calculated incidence of symptomatic COVID-19 per 1000/person days at risk and incidence rate ratio (IRR). RESULTS: Among 2151 SOTRs, 912 were fully vaccinated, and 1239 were controls (1151 unvaccinated, 88 partially vaccinated). Almost 70% of vaccinated subjects received the mRNA-1273 vaccine. There were 65 cases of COVID-19 that occurred during the study period - four occurred among fully vaccinated individuals and 61 among controls (including two in partially vaccinated individuals). Incidence rate for COVID-19 was 0.065 (95% CI 0.024-0.17) per 1000 person days in vaccinated versus 0.34 (95% CI 0.26-0.44) per 1000/person days in the control group; IRR was 0.19 (95% CI 0.049 -0.503, p < 0.005). There were no COVID-19 related deaths in the four breakthrough infections and two of 61 (3.3%) among controls. CONCLUSION: We demonstrate real world clinical effectiveness of COVID-19 vaccination in SOTRs with an almost 80% reduction in the incidence of symptomatic COVID-19 versus unvaccinated SOTRs during the same time.
  • |*COVID-19[MESH]
  • |*Organ Transplantation/adverse effects[MESH]
  • |2019-nCoV Vaccine mRNA-1273[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2[MESH]
  • |Transplant Recipients[MESH]
  • |Treatment Outcome[MESH]


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