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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biomed+Pharmacother 2021 ; 141 (ä): 111922 Nephropedia Template TP
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Lecithinized superoxide dismutase in the past and in the present: Any role in the actual pandemia of COVID-19? #MMPMID34323703
Farella I; Panza R; Capozza M; Laforgia N
Biomed Pharmacother 2021[Sep]; 141 (ä): 111922 PMID34323703show ga
The Coronavirus disease 19 (Covid-19) pandemic is devastating the public health: it is urgent to find a viable therapy to reduce the multiorgan damage of the disease. A validated therapeutic protocol is still missing. The most severe forms of the disease are related to an exaggerated inflammatory response. The pivotal role of reactive oxygen species (ROS) in the amplification of inflammation makes the antioxidants a potential therapy, but clinical trials are needed. The lecitinized superoxide dismutase (PC-SOD) could represent a possibility because of bioaviability, safety, and its modulatory effect on the innate immune response in reducing the harmful consequences of oxidative stress. In this review we summarize the evidence on lecitinized superoxide dismutase in animal and human studies, to highlight the rationale for using the PC-SOD to treat COVID-19.
|*COVID-19 Drug Treatment[MESH]
|Animals[MESH]
|Antioxidants/pharmacology/therapeutic use[MESH]
|COVID-19/diagnosis/metabolism[MESH]
|Humans[MESH]
|Multiple Organ Failure/diagnosis/drug therapy/metabolism[MESH]