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10.7554/eLife.69317 http://scihub22266oqcxt.onion/10.7554/eLife.69317 34323691!8352583!34323691     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2021 ; 10 (ä): ä Nephropedia Template TP {{tp|p=34323691|t=2021. Reduced antibody cross-reactivity following infection with B 1 1 7 than with parental SARS-CoV-2 strains |pdf=|usr=}}{{34323691}} gab.com Text Reduced antibody cross-reactivity following infection with B 1 1 7 than with parental SARS-CoV-2 strains JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=34323691 #FOAvip BACKGROUND: The degree of heterotypic immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging variants and the success of vaccination campaigns, but remains incompletely understood. METHODS: We examined the immunogenicity of SARS-CoV-2 variant B.1.1.7 (Alpha) that arose in the United Kingdom and spread globally. We determined titres of spike glycoprotein-binding antibodies and authentic virus neutralising antibodies induced by B.1.1.7 infection to infer homotypic and heterotypic immunity. RESULTS: Antibodies elicited by B.1.1.7 infection exhibited significantly reduced recognition and neutralisation of parental strains or of the South Africa variant B.1.351 (Beta) than of the infecting variant. The drop in cross-reactivity was significantly more pronounced following B.1.1.7 than parental strain infection. CONCLUSIONS: The results indicate that heterotypic immunity induced by SARS-CoV-2 variants is asymmetric. FUNDING: This work was supported by the Francis Crick Institute and the Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg. Twit Text FOAVip Reduced antibody cross-reactivity following infection with B 1 1 7 than with parental SARS-CoV-2 strains ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=34323691 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34323691 #FOAvip English Wikipedia <ref>{{Cite pmid|34323691}}</ref> Reduced antibody cross-reactivity following infection with B 1 1 7 than with parental SARS-CoV-2 strains #MMPMID34323691 Faulkner N; Ng KW; Wu MY; Harvey R; Margaritis M; Paraskevopoulou S; Houlihan C; Hussain S; Greco M; Bolland W; Warchal S; Heaney J; Rickman H; Spyer M; Frampton D; Byott M; de Oliveira T; Sigal A; Kjaer S; Swanton C; Gandhi S; Beale R; Gamblin SJ; McCauley JW; Daniels RS; Howell M; Bauer D; Nastouli E; Kassiotis G Elife 2021[Jul]; 10 (ä): ä PMID34323691show ga BACKGROUND: The degree of heterotypic immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging variants and the success of vaccination campaigns, but remains incompletely understood. METHODS: We examined the immunogenicity of SARS-CoV-2 variant B.1.1.7 (Alpha) that arose in the United Kingdom and spread globally. We determined titres of spike glycoprotein-binding antibodies and authentic virus neutralising antibodies induced by B.1.1.7 infection to infer homotypic and heterotypic immunity. RESULTS: Antibodies elicited by B.1.1.7 infection exhibited significantly reduced recognition and neutralisation of parental strains or of the South Africa variant B.1.351 (Beta) than of the infecting variant. The drop in cross-reactivity was significantly more pronounced following B.1.1.7 than parental strain infection. CONCLUSIONS: The results indicate that heterotypic immunity induced by SARS-CoV-2 variants is asymmetric. FUNDING: This work was supported by the Francis Crick Institute and the Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg. |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19/epidemiology/*immunology/*virology[MESH] |Cross Reactions[MESH] |Humans[MESH] |Parents[MESH] |SARS-CoV-2/*immunology[MESH] |South Africa/epidemiology[MESH] |Spike Glycoprotein, Coronavirus[MESH]Reduced antibody cross-reactivity following infection with B 1 1 7 tha(epmc).pdf DeepDyve Pubget Overpricing