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10.3389/fimmu.2021.687449 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.687449 34322120!8312095!34322120     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 687449 Nephropedia Template TP {{tp|p=34322120|t=2021. Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody Serology |pdf=|usr=}}{{34322120}} gab.com Text Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody Serology JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34322120 #FOAvip Despite RT-PCR confirmed COVID-19, specific antibodies to SARS-CoV-2 spike are undetectable in serum in approximately 10% of convalescent patients after mild disease course. This raises the question of induction and persistence of SARS-CoV-2-reactive T cells in these convalescent individuals. Using flow cytometry, we assessed specific SARS-CoV-2 and human endemic coronaviruses (HCoV-229E, -OC43) reactive T cells after stimulation with spike and nucleocapsid peptide pools and analyzed cytokine polyfunctionality (IFNgamma, TNFalpha, and IL-2) in seropositive and seronegative convalescent COVID-19 patients as well as in unexposed healthy controls. Stimulation with SARS-CoV-2 spike and nucleocapsid (NCAP) as well as HCoV spike peptide pools elicited a similar T cell response in seropositive and seronegative post COVID-19 patients. Significantly higher frequencies of polyfunctional cytokine nucleocapsid reactive CD4+ T cells (triple positive for IFNgamma, TNFalpha, and IL-2) were observed in both, seropositive (p = 0.008) and seronegative (p = 0.04), COVID-19 convalescent compared to healthy controls and were detectable up to day 162 post RT-PCR positivity in seronegative convalescents. Our data indicate an important role of NCAP-specific T cells for viral control. Twit Text FOAVip Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody Serology ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34322120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34322120 #FOAvip English Wikipedia <ref>{{Cite pmid|34322120}}</ref> Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody Serology #MMPMID34322120 Steiner S; Schwarz T; Corman VM; Sotzny F; Bauer S; Drosten C; Volk HD; Scheibenbogen C; Hanitsch LG Front Immunol 2021[]; 12 (ä): 687449 PMID34322120show ga Despite RT-PCR confirmed COVID-19, specific antibodies to SARS-CoV-2 spike are undetectable in serum in approximately 10% of convalescent patients after mild disease course. This raises the question of induction and persistence of SARS-CoV-2-reactive T cells in these convalescent individuals. Using flow cytometry, we assessed specific SARS-CoV-2 and human endemic coronaviruses (HCoV-229E, -OC43) reactive T cells after stimulation with spike and nucleocapsid peptide pools and analyzed cytokine polyfunctionality (IFNgamma, TNFalpha, and IL-2) in seropositive and seronegative convalescent COVID-19 patients as well as in unexposed healthy controls. Stimulation with SARS-CoV-2 spike and nucleocapsid (NCAP) as well as HCoV spike peptide pools elicited a similar T cell response in seropositive and seronegative post COVID-19 patients. Significantly higher frequencies of polyfunctional cytokine nucleocapsid reactive CD4+ T cells (triple positive for IFNgamma, TNFalpha, and IL-2) were observed in both, seropositive (p = 0.008) and seronegative (p = 0.04), COVID-19 convalescent compared to healthy controls and were detectable up to day 162 post RT-PCR positivity in seronegative convalescents. Our data indicate an important role of NCAP-specific T cells for viral control. |Adult[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |COVID-19 Serological Testing[MESH] |COVID-19/*immunology[MESH] |Cells, Cultured[MESH] |Convalescence[MESH] |Coronavirus 229E, Human/*physiology[MESH] |Coronavirus Nucleocapsid Proteins/immunology[MESH] |Female[MESH] |Humans[MESH] |Lymphocyte Activation[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*physiology[MESH]Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-(epmc).pdf DeepDyve Pubget Overpricing