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10.1038/s41467-021-24817-y http://scihub22266oqcxt.onion/10.1038/s41467-021-24817-y 34321474!8319209!34321474     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34321474&cmd=llinks): Failed to open stream: HTTP request failed! 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IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro |pdf=|usr=}}{{34321474}} gab.com Text IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34321474 #FOAvip Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. However, endogenous IFITM expression supports efficient infection of SARS-CoV-2 in human lung cells. Our results indicate that the SARS-CoV-2 Spike protein interacts with IFITMs and hijacks them for efficient viral infection. IFITM proteins were expressed and further induced by interferons in human lung, gut, heart and brain cells. IFITM-derived peptides and targeting antibodies inhibit SARS-CoV-2 entry and replication in human lung cells, cardiomyocytes and gut organoids. Our results show that IFITM proteins are cofactors for efficient SARS-CoV-2 infection of human cell types representing in vivo targets for viral transmission, dissemination and pathogenesis and are potential targets for therapeutic approaches. Twit Text FOAVip IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34321474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34321474 #FOAvip English Wikipedia <ref>{{Cite pmid|34321474}}</ref> IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro #MMPMID34321474 Prelli Bozzo C; Nchioua R; Volcic M; Koepke L; Kruger J; Schutz D; Heller S; Sturzel CM; Kmiec D; Conzelmann C; Muller J; Zech F; Braun E; Gross R; Wettstein L; Weil T; Weiss J; Diofano F; Rodriguez Alfonso AA; Wiese S; Sauter D; Munch J; Goffinet C; Catanese A; Schon M; Boeckers TM; Stenger S; Sato K; Just S; Kleger A; Sparrer KMJ; Kirchhoff F Nat Commun 2021[Jul]; 12 (1): 4584 PMID34321474show ga Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. However, endogenous IFITM expression supports efficient infection of SARS-CoV-2 in human lung cells. Our results indicate that the SARS-CoV-2 Spike protein interacts with IFITMs and hijacks them for efficient viral infection. IFITM proteins were expressed and further induced by interferons in human lung, gut, heart and brain cells. IFITM-derived peptides and targeting antibodies inhibit SARS-CoV-2 entry and replication in human lung cells, cardiomyocytes and gut organoids. Our results show that IFITM proteins are cofactors for efficient SARS-CoV-2 infection of human cell types representing in vivo targets for viral transmission, dissemination and pathogenesis and are potential targets for therapeutic approaches. |Amino Acid Sequence[MESH] |Angiotensin-Converting Enzyme 2/antagonists & inhibitors/*genetics/metabolism[MESH] |Antibodies, Neutralizing/pharmacology[MESH] |Antigens, Differentiation/*genetics/metabolism[MESH] |Binding Sites[MESH] |COVID-19/virology[MESH] |Gene Expression Regulation[MESH] |Host-Pathogen Interactions/drug effects/genetics[MESH] |Humans[MESH] |Interferon-beta/pharmacology[MESH] |Membrane Proteins/antagonists & inhibitors/*genetics/metabolism[MESH] |Protein Binding[MESH] |Protein Interaction Domains and Motifs[MESH] |RNA, Small Interfering/genetics/metabolism[MESH] |RNA-Binding Proteins/antagonists & inhibitors/*genetics/metabolism[MESH] |SARS-CoV-2/drug effects/*genetics/metabolism[MESH] |Sequence Alignment[MESH] |Sequence Homology, Amino Acid[MESH] |Spike Glycoprotein, Coronavirus/*genetics/metabolism[MESH]IFITM proteins promote SARS-CoV-2 infection and are targets for virus (epmc).pdf DeepDyve Pubget Overpricing