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Nature 2021[Sep]; 597 (7875): 268-273 PMID34320609show ga
SARS-CoV-2 spike mRNA vaccines(1-3) mediate protection from severe disease as early as ten days after prime vaccination(3), when neutralizing antibodies are hardly detectable(4-6). Vaccine-induced CD8(+) T cells may therefore be the main mediators of protection at this early stage(7,8). The details of their induction, comparison to natural infection, and association with other arms of vaccine-induced immunity remain, however, incompletely understood. Here we show on a single-epitope level that a stable and fully functional CD8(+) T cell response is vigorously mobilized one week after prime vaccination with bnt162b2, when circulating CD4(+) T cells and neutralizing antibodies are still weakly detectable. Boost vaccination induced a robust expansion that generated highly differentiated effector CD8(+) T cells; however, neither the functional capacity nor the memory precursor T cell pool was affected. Compared with natural infection, vaccine-induced early memory T cells exhibited similar functional capacities but a different subset distribution. Our results indicate that CD8(+) T cells are important effector cells, are expanded in the early protection window after prime vaccination, precede maturation of other effector arms of vaccine-induced immunity and are stably maintained after boost vaccination.
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Nature 2021 ; 597 (7875): 268-273
