Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.celrep.2021.109479 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109479 34320401!8289695!34320401     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 36 (5): 109479 Nephropedia Template TP {{tp|p=34320401|t=2021. Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication |pdf=|usr=}}{{34320401}} gab.com Text Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34320401 #FOAvip Coronaviruses rely on host membranes for entry, establishment of replication centers, and egress. Compounds targeting cellular membrane biology and lipid biosynthetic pathways have previously shown promise as antivirals and are actively being pursued as treatments for other conditions. Here, we test small molecule inhibitors that target the PI3 kinase VPS34 or fatty acid metabolism for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) activity. Our studies determine that compounds targeting VPS34 are potent SARS-CoV-2 inhibitors. Mechanistic studies with compounds targeting multiple steps up- and downstream of fatty acid synthase (FASN) identify the importance of triacylglycerol production and protein palmitoylation as requirements for efficient viral RNA synthesis and infectious virus production. Further, FASN knockout results in significantly impaired SARS-CoV-2 replication that can be rescued with fatty acid supplementation. Together, these studies clarify roles for VPS34 and fatty acid metabolism in SARS-CoV-2 replication and identify promising avenues for the development of countermeasures against SARS-CoV-2. Twit Text FOAVip Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34320401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34320401 #FOAvip English Wikipedia <ref>{{Cite pmid|34320401}}</ref> Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication #MMPMID34320401 Williams CG; Jureka AS; Silvas JA; Nicolini AM; Chvatal SA; Carlson-Stevermer J; Oki J; Holden K; Basler CF Cell Rep 2021[Aug]; 36 (5): 109479 PMID34320401show ga Coronaviruses rely on host membranes for entry, establishment of replication centers, and egress. Compounds targeting cellular membrane biology and lipid biosynthetic pathways have previously shown promise as antivirals and are actively being pursued as treatments for other conditions. Here, we test small molecule inhibitors that target the PI3 kinase VPS34 or fatty acid metabolism for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) activity. Our studies determine that compounds targeting VPS34 are potent SARS-CoV-2 inhibitors. Mechanistic studies with compounds targeting multiple steps up- and downstream of fatty acid synthase (FASN) identify the importance of triacylglycerol production and protein palmitoylation as requirements for efficient viral RNA synthesis and infectious virus production. Further, FASN knockout results in significantly impaired SARS-CoV-2 replication that can be rescued with fatty acid supplementation. Together, these studies clarify roles for VPS34 and fatty acid metabolism in SARS-CoV-2 replication and identify promising avenues for the development of countermeasures against SARS-CoV-2. |Aminopyridines/pharmacology[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19/*virology[MESH] |Caco-2 Cells[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Class III Phosphatidylinositol 3-Kinases/*antagonists & inhibitors/metabolism[MESH] |Fatty Acid Synthases/drug effects/genetics[MESH] |Gene Knockout Techniques[MESH] |Humans[MESH] |Lipid Metabolism/*drug effects[MESH] |Lipoylation/drug effects[MESH] |Pyrimidines/pharmacology[MESH] |RNA, Viral/metabolism[MESH] |SARS-CoV-2/*drug effects/*physiology[MESH] |Triglycerides/metabolism[MESH] |Vero Cells[MESH]Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 repl(epmc).pdf DeepDyve Pubget Overpricing