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10.1021/acsinfecdis.1c00248 http://scihub22266oqcxt.onion/10.1021/acsinfecdis.1c00248 34319698!8353987!34319698     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Infect+Dis 2021 ; 7 (9): 2596-2603 Nephropedia Template TP {{tp|p=34319698|t=2021. Reproducible Breath Metabolite Changes in Children with SARS-CoV-2 Infection |pdf=|usr=}}{{34319698}} gab.com Text Reproducible Breath Metabolite Changes in Children with SARS-CoV-2 Infection JO: ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34319698 #FOAvip SARS-CoV-2 infection is diagnosed through detection of specific viral nucleic acid or antigens from respiratory samples. These techniques are relatively expensive, slow, and susceptible to false-negative results. A rapid noninvasive method to detect infection would be highly advantageous. Compelling evidence from canine biosensors and studies of adults with COVID-19 suggests that infection reproducibly alters human volatile organic compound (VOC) profiles. To determine whether pediatric infection is associated with VOC changes, we enrolled SARS-CoV-2 infected and uninfected children admitted to a major pediatric academic medical center. Breath samples were collected from children and analyzed through state-of-the-art GCxGC-ToFMS. Isolated features included 84 targeted VOCs. Candidate biomarkers that were correlated with infection status were subsequently validated in a second, independent cohort of children. We thus find that six volatile organic compounds are significantly and reproducibly increased in the breath of SARS-CoV-2 infected children. Three aldehydes (octanal, nonanal, and heptanal) drew special attention, as aldehydes are also elevated in the breath of adults with COVID-19. Together, these biomarkers demonstrate high accuracy for distinguishing pediatric SARS-CoV-2 infection and support the ongoing development of novel breath-based diagnostics. Twit Text FOAVip Reproducible Breath Metabolite Changes in Children with SARS-CoV-2 Infection ????ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34319698 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34319698 #FOAvip English Wikipedia <ref>{{Cite pmid|34319698}}</ref> Reproducible Breath Metabolite Changes in Children with SARS-CoV-2 Infection #MMPMID34319698 Berna AZ; Akaho EH; Harris RM; Congdon M; Korn E; Neher S; M'Farrej M; Burns J; Odom John AR ACS Infect Dis 2021[Sep]; 7 (9): 2596-2603 PMID34319698show ga SARS-CoV-2 infection is diagnosed through detection of specific viral nucleic acid or antigens from respiratory samples. These techniques are relatively expensive, slow, and susceptible to false-negative results. A rapid noninvasive method to detect infection would be highly advantageous. Compelling evidence from canine biosensors and studies of adults with COVID-19 suggests that infection reproducibly alters human volatile organic compound (VOC) profiles. To determine whether pediatric infection is associated with VOC changes, we enrolled SARS-CoV-2 infected and uninfected children admitted to a major pediatric academic medical center. Breath samples were collected from children and analyzed through state-of-the-art GCxGC-ToFMS. Isolated features included 84 targeted VOCs. Candidate biomarkers that were correlated with infection status were subsequently validated in a second, independent cohort of children. We thus find that six volatile organic compounds are significantly and reproducibly increased in the breath of SARS-CoV-2 infected children. Three aldehydes (octanal, nonanal, and heptanal) drew special attention, as aldehydes are also elevated in the breath of adults with COVID-19. Together, these biomarkers demonstrate high accuracy for distinguishing pediatric SARS-CoV-2 infection and support the ongoing development of novel breath-based diagnostics. äReproducible Breath Metabolite Changes in Children with SARS-CoV-2 Inf(epmc).pdf DeepDyve Pubget Overpricing