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10.1038/s41467-021-24824-z

http://scihub22266oqcxt.onion/10.1038/s41467-021-24824-z
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34315903!8316582!34315903
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suck abstract from ncbi


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pmid34315903      Nat+Commun 2021 ; 12 (1): 4569
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  • Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization #MMPMID34315903
  • Pathak GA; Singh K; Miller-Fleming TW; Wendt FR; Ehsan N; Hou K; Johnson R; Lu Z; Gopalan S; Yengo L; Mohammadi P; Pasaniuc B; Polimanti R; Davis LK; Mancuso N
  • Nat Commun 2021[Jul]; 12 (1): 4569 PMID34315903show ga
  • Despite rapid progress in characterizing the role of host genetics in SARS-Cov-2 infection, there is limited understanding of genes and pathways that contribute to COVID-19. Here, we integrate a genome-wide association study of COVID-19 hospitalization (7,885 cases and 961,804 controls from COVID-19 Host Genetics Initiative) with mRNA expression, splicing, and protein levels (n = 18,502). We identify 27 genes related to inflammation and coagulation pathways whose genetically predicted expression was associated with COVID-19 hospitalization. We functionally characterize the 27 genes using phenome- and laboratory-wide association scans in Vanderbilt Biobank (n = 85,460) and identified coagulation-related clinical symptoms, immunologic, and blood-cell-related biomarkers. We replicate these findings across trans-ethnic studies and observed consistent effects in individuals of diverse ancestral backgrounds in Vanderbilt Biobank, pan-UK Biobank, and Biobank Japan. Our study highlights and reconfirms putative causal genes impacting COVID-19 severity and symptomology through the host inflammatory response.
  • |COVID-19/genetics/*metabolism[MESH]
  • |Genetic Predisposition to Disease/genetics[MESH]
  • |Genome-Wide Association Study[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Polymorphism, Single Nucleotide/genetics[MESH]


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