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10.1038/s41467-021-24824-z http://scihub22266oqcxt.onion/10.1038/s41467-021-24824-z 34315903!8316582!34315903     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34315903.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2021 ; 12 (1): 4569 Nephropedia Template TP {{tp|p=34315903|t=2021. Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization |pdf=|usr=}}{{34315903}} gab.com Text Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34315903 #FOAvip Despite rapid progress in characterizing the role of host genetics in SARS-Cov-2 infection, there is limited understanding of genes and pathways that contribute to COVID-19. Here, we integrate a genome-wide association study of COVID-19 hospitalization (7,885 cases and 961,804 controls from COVID-19 Host Genetics Initiative) with mRNA expression, splicing, and protein levels (n = 18,502). We identify 27 genes related to inflammation and coagulation pathways whose genetically predicted expression was associated with COVID-19 hospitalization. We functionally characterize the 27 genes using phenome- and laboratory-wide association scans in Vanderbilt Biobank (n = 85,460) and identified coagulation-related clinical symptoms, immunologic, and blood-cell-related biomarkers. We replicate these findings across trans-ethnic studies and observed consistent effects in individuals of diverse ancestral backgrounds in Vanderbilt Biobank, pan-UK Biobank, and Biobank Japan. Our study highlights and reconfirms putative causal genes impacting COVID-19 severity and symptomology through the host inflammatory response. Twit Text FOAVip Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34315903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34315903 #FOAvip English Wikipedia <ref>{{Cite pmid|34315903}}</ref> Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization #MMPMID34315903 Pathak GA; Singh K; Miller-Fleming TW; Wendt FR; Ehsan N; Hou K; Johnson R; Lu Z; Gopalan S; Yengo L; Mohammadi P; Pasaniuc B; Polimanti R; Davis LK; Mancuso N Nat Commun 2021[Jul]; 12 (1): 4569 PMID34315903show ga Despite rapid progress in characterizing the role of host genetics in SARS-Cov-2 infection, there is limited understanding of genes and pathways that contribute to COVID-19. Here, we integrate a genome-wide association study of COVID-19 hospitalization (7,885 cases and 961,804 controls from COVID-19 Host Genetics Initiative) with mRNA expression, splicing, and protein levels (n = 18,502). We identify 27 genes related to inflammation and coagulation pathways whose genetically predicted expression was associated with COVID-19 hospitalization. We functionally characterize the 27 genes using phenome- and laboratory-wide association scans in Vanderbilt Biobank (n = 85,460) and identified coagulation-related clinical symptoms, immunologic, and blood-cell-related biomarkers. We replicate these findings across trans-ethnic studies and observed consistent effects in individuals of diverse ancestral backgrounds in Vanderbilt Biobank, pan-UK Biobank, and Biobank Japan. Our study highlights and reconfirms putative causal genes impacting COVID-19 severity and symptomology through the host inflammatory response. |COVID-19/genetics/*metabolism[MESH] |Genetic Predisposition to Disease/genetics[MESH] |Genome-Wide Association Study[MESH] |Hospitalization[MESH] |Humans[MESH] |Polymorphism, Single Nucleotide/genetics[MESH]Integrative genomic analyses identify susceptibility genes underlying (epmc).pdf DeepDyve Pubget Overpricing