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10.1038/s41467-021-24807-0

http://scihub22266oqcxt.onion/10.1038/s41467-021-24807-0
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suck abstract from ncbi


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pmid34315893      Nat+Commun 2021 ; 12 (1): 4567
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  • Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets #MMPMID34315893
  • Lee JS; Koh JY; Yi K; Kim YI; Park SJ; Kim EH; Kim SM; Park SH; Ju YS; Choi YK; Park SH
  • Nat Commun 2021[Jul]; 12 (1): 4567 PMID34315893show ga
  • Few studies have used a longitudinal approach to describe the immune response to SARS-CoV-2 infection. Here, we perform single-cell RNA sequencing of bronchoalveolar lavage fluid cells longitudinally obtained from SARS-CoV-2-infected ferrets. Landscape analysis of the lung immune microenvironment shows distinct changes in cell proportions and characteristics compared to uninfected control, at 2 and 5 days post-infection (dpi). Macrophages are classified into 10 distinct subpopulations with transcriptome changes among monocyte-derived infiltrating macrophages and differentiated M1/M2 macrophages, notably at 2 dpi. Moreover, trajectory analysis reveals gene expression changes from monocyte-derived infiltrating macrophages toward M1 or M2 macrophages and identifies a macrophage subpopulation that has rapidly undergone SARS-CoV-2-mediated activation of inflammatory responses. Finally, we find that M1 or M2 macrophages show distinct patterns of gene modules downregulated by immune-modulatory drugs. Overall, these results elucidate fundamental aspects of the immune response dynamics provoked by SARS-CoV-2 infection.
  • |Animals[MESH]
  • |Bronchoalveolar Lavage Fluid[MESH]
  • |COVID-19/*genetics/*metabolism[MESH]
  • |Ferrets[MESH]


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