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10.1136/jim-2021-001871

http://scihub22266oqcxt.onion/10.1136/jim-2021-001871
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suck abstract from ncbi


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pmid34315800      J+Investig+Med 2021 ; 69 (8): 1426-1433
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  • Behaviors, symptoms, and outcomes of North American patients with autoimmune hepatitis during the COVID-19 pandemic #MMPMID34315800
  • Vuppalanchi V; Gelow K; Green K; Vuppalanchi R; Lammert C
  • J Investig Med 2021[Dec]; 69 (8): 1426-1433 PMID34315800show ga
  • The management of patients with autoimmune hepatitis (AIH) in the era of SARS-CoV-2 is challenging given minimal published clinical data. We used a large cohort of patients with AIH across the USA to investigate the differences in known risk factors for severe SARS-CoV-2 and AIH characteristics among patients who experienced symptoms consistent with COVID-19 illness versus those who did not. Additionally, we explored the effect of living through the SARS-CoV-2 pandemic on the extrahepatic symptoms and behaviors of patients with AIH. An invitation to complete a COVID-19-specific questionnaire was publicized in well-established social media cohorts of patients with AIH. Eligibility criteria were age >/=18 years, US residency, and an AIH diagnosis by a physician. A total of 420 individuals were eligible for the study. Symptoms consistent with COVID-19 were reported in 11% (n=48) with 3 patients requiring hospitalizations. Body mass index (BMI) >40 kg/m(2) (23% vs 10%, p=0.01) and exposure to house (33% vs 3%, p=0.0001) or work (38% vs 17%, p=0.02) contacts with COVID-19 were factors found higher in those with symptoms. Cirrhosis or steroid use or immunosuppression was not significantly different between symptomatic and non-symptomatic groups. Worsening fatigue (45% vs 30%, p=0.06), anxiety (89% vs 70%, p=0.08), and itch (40% vs 18%, p=0.03) were more common among those reporting COVID-19 symptoms compared with those without. BMI >40 kg/m(2) and exposure to contacts with COVID-19 illness but not cirrhosis or immunosuppression were associated with increased risk of COVID-19 illness in patients with AIH.
  • |*COVID-19/epidemiology[MESH]
  • |*Hepatitis, Autoimmune/epidemiology[MESH]
  • |Anxiety[MESH]
  • |Fatigue[MESH]
  • |Humans[MESH]
  • |Immunosuppression Therapy[MESH]
  • |Liver Cirrhosis[MESH]
  • |Pandemics[MESH]
  • |Pruritus[MESH]


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