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10.1182/blood.2021011871 http://scihub22266oqcxt.onion/10.1182/blood.2021011871 34315173!8321687!34315173     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34315173&cmd=llinks): Failed to open stream: HTTP request failed! 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Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets |pdf=|usr=}}{{34315173}} gab.com Text Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=34315173 #FOAvip A subset of patients with coronavirus disease 2019 (COVID-19) become critically ill, suffering from severe respiratory problems and also increased rates of thrombosis. The causes of thrombosis in severely ill patients with COVID-19 are still emerging, but the coincidence of critical illness with the timing of the onset of adaptive immunity could implicate an excessive immune response. We hypothesized that platelets might be susceptible to activation by anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) antibodies and might contribute to thrombosis. We found that immune complexes containing recombinant SARS-CoV-2 spike protein and anti-spike immunoglobulin G enhanced platelet-mediated thrombosis on von Willebrand factor in vitro, but only when the glycosylation state of the Fc domain was modified to correspond with the aberrant glycosylation previously identified in patients with severe COVID-19. Furthermore, we found that activation was dependent on FcgammaRIIA, and we provide in vitro evidence that this pathogenic platelet activation can be counteracted by the therapeutic small molecules R406 (fostamatinib) and ibrutinib, which inhibit tyrosine kinases Syk and Btk, respectively, or by the P2Y12 antagonist cangrelor. Twit Text FOAVip Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=34315173 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34315173 #FOAvip English Wikipedia <ref>{{Cite pmid|34315173}}</ref> Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets #MMPMID34315173 Bye AP; Hoepel W; Mitchell JL; Jegouic S; Loureiro S; Sage T; Vidarsson G; Nouta J; Wuhrer M; de Taeye S; van Gils M; Kriek N; Cooper N; Jones I; den Dunnen J; Gibbins JM Blood 2021[Oct]; 138 (16): 1481-1489 PMID34315173show ga A subset of patients with coronavirus disease 2019 (COVID-19) become critically ill, suffering from severe respiratory problems and also increased rates of thrombosis. The causes of thrombosis in severely ill patients with COVID-19 are still emerging, but the coincidence of critical illness with the timing of the onset of adaptive immunity could implicate an excessive immune response. We hypothesized that platelets might be susceptible to activation by anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) antibodies and might contribute to thrombosis. We found that immune complexes containing recombinant SARS-CoV-2 spike protein and anti-spike immunoglobulin G enhanced platelet-mediated thrombosis on von Willebrand factor in vitro, but only when the glycosylation state of the Fc domain was modified to correspond with the aberrant glycosylation previously identified in patients with severe COVID-19. Furthermore, we found that activation was dependent on FcgammaRIIA, and we provide in vitro evidence that this pathogenic platelet activation can be counteracted by the therapeutic small molecules R406 (fostamatinib) and ibrutinib, which inhibit tyrosine kinases Syk and Btk, respectively, or by the P2Y12 antagonist cangrelor. |Antibodies, Viral/blood/immunology[MESH] |Antigen-Antibody Complex/immunology[MESH] |Blood Platelets/immunology/metabolism/*pathology[MESH] |COVID-19/*complications/immunology/virology[MESH] |Glycosylation[MESH] |Humans[MESH] |Immunoglobulin G/*immunology[MESH] |Platelet Activation/immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Spike Glycoprotein, Coronavirus/*metabolism[MESH] |Thrombosis/immunology/*pathology/virology[MESH]Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic(epmc).pdf DeepDyve Pubget Overpricing