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10.1016/j.advms.2021.07.009 http://scihub22266oqcxt.onion/10.1016/j.advms.2021.07.009 34315012!8292100!34315012     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Med+Sci 2021 ; 66 (2): 372-380 Nephropedia Template TP {{tp|p=34315012|t=2021. INR and COVID-19 severity and mortality: A systematic review with meta-analysis and meta-regression |pdf=|usr=}}{{34315012}} gab.com Text INR and COVID-19 severity and mortality: A systematic review with meta-analysis and meta-regression JO: Adv Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=34315012 #FOAvip OBJECTIVES: D-dimer elevations, suggesting a pro-thrombotic state and coagulopathy, predict adverse outcomes in coronavirus disease 2019 (COVID-19). However, the clinical significance of other coagulation markers, particularly the international normalized ratio (INR), is not well established. We conducted a systematic review and meta-analysis of the INR in COVID-19. METHODS: A literature search was conducted in PubMed, Web of Science and Scopus, between January 2020 and February 2021, for studies reporting INR values, measures of COVID-19 severity, and mortality (PROSPERO registration number: CRD42021241468). RESULTS: Thirty-eight studies in 7440 COVID-19 patients with low disease severity or survivor status during follow up (50 ?% males, mean age 57 years) and 2331 with high severity or non-survivor status (60 ?% males, mean age 69 years) were identified. The INR was significantly prolonged in patients with severe disease or non-survivor status than in patients with mild disease or survivor status (standard mean difference, SMD, 0.60; 95 ?% confidence interval, CI 0.42 to 0.77; p ?< ?0.001). There was extreme between-study heterogeneity (I(2) ?= ?90.2 ?%; p ?< ?0.001). Sensitivity analysis, performed by sequentially removing each study and re-assessing the pooled estimates, showed that the magnitude and direction of the effect size was not modified. The Begg's and Egger's t-tests did not show publication bias. In meta-regression, the SMD of the INR was significantly associated with C-reactive protein (p ?= ?0.048) and D-dimer (p ?= ?0.001). CONCLUSIONS: Prolonged INR values were significantly associated with COVID-19 severity and mortality. Both INR prolongation and D-dimer elevations can be useful in diagnosing COVID-19-associated coagulopathy and predicting clinical outcomes. Twit Text FOAVip INR and COVID-19 severity and mortality: A systematic review with meta-analysis and meta-regression ????Adv Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=34315012 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34315012 #FOAvip English Wikipedia <ref>{{Cite pmid|34315012}}</ref> INR and COVID-19 severity and mortality: A systematic review with meta-analysis and meta-regression #MMPMID34315012 Zinellu A; Paliogiannis P; Carru C; Mangoni AA Adv Med Sci 2021[Sep]; 66 (2): 372-380 PMID34315012show ga OBJECTIVES: D-dimer elevations, suggesting a pro-thrombotic state and coagulopathy, predict adverse outcomes in coronavirus disease 2019 (COVID-19). However, the clinical significance of other coagulation markers, particularly the international normalized ratio (INR), is not well established. We conducted a systematic review and meta-analysis of the INR in COVID-19. METHODS: A literature search was conducted in PubMed, Web of Science and Scopus, between January 2020 and February 2021, for studies reporting INR values, measures of COVID-19 severity, and mortality (PROSPERO registration number: CRD42021241468). RESULTS: Thirty-eight studies in 7440 COVID-19 patients with low disease severity or survivor status during follow up (50 ?% males, mean age 57 years) and 2331 with high severity or non-survivor status (60 ?% males, mean age 69 years) were identified. The INR was significantly prolonged in patients with severe disease or non-survivor status than in patients with mild disease or survivor status (standard mean difference, SMD, 0.60; 95 ?% confidence interval, CI 0.42 to 0.77; p ?< ?0.001). There was extreme between-study heterogeneity (I(2) ?= ?90.2 ?%; p ?< ?0.001). Sensitivity analysis, performed by sequentially removing each study and re-assessing the pooled estimates, showed that the magnitude and direction of the effect size was not modified. The Begg's and Egger's t-tests did not show publication bias. In meta-regression, the SMD of the INR was significantly associated with C-reactive protein (p ?= ?0.048) and D-dimer (p ?= ?0.001). CONCLUSIONS: Prolonged INR values were significantly associated with COVID-19 severity and mortality. Both INR prolongation and D-dimer elevations can be useful in diagnosing COVID-19-associated coagulopathy and predicting clinical outcomes. |*COVID-19/blood/complications/diagnosis/mortality[MESH] |*International Normalized Ratio/methods/statistics & numerical data[MESH] |*Thrombophilia/blood/diagnosis/etiology[MESH] |Fibrin Fibrinogen Degradation Products/*analysis[MESH] |Humans[MESH] |Mortality[MESH] |SARS-CoV-2[MESH]INR and COVID-19 severity and mortality: A systematic review with meta(epmc).pdf DeepDyve Pubget Overpricing