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10.1016/j.jcv.2021.104916

http://scihub22266oqcxt.onion/10.1016/j.jcv.2021.104916
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suck abstract from ncbi


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pmid34315010      J+Clin+Virol 2021 ; 142 (ä): 104916
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  • Dynamics of breast milk antibody titer in the six months following SARS-CoV-2 infection #MMPMID34315010
  • Duncombe CJ; McCulloch DJ; Shuey KD; Logue JK; Franko NM; Wolf CR; Frivold CJ; Chu HY
  • J Clin Virol 2021[Sep]; 142 (ä): 104916 PMID34315010show ga
  • BACKGROUND: While a growing body of literature describes antibody dynamics in serum, little is known about breast milk antibody titers in the months following SARS-CoV-2 infection. OBJECTIVES: We evaluated the dynamics of the humoral immune response to SARS-CoV-2 in two women who were breastfeeding when infected. We assessed paired breast milk and serum samples for six months post-infection for antibodies specific to the SARS-CoV-2 receptor binding domain (RBD) of the spike protein. RESULTS: Starting at 10 days after symptom onset, IgA antibody levels were persistent over a 6-month time period in human milk. For both mothers, no detectable IgA was found in the samples collected pre-symptom onset. RBD-specific IgG and IgM antibodies in tandem serum collected from the two donors demonstrated stable IgG levels over the six-month time period post-symptom onset. CONCLUSIONS: We found that breastfeeding mothers produced a durable IgA response for up to six months following COVID-19 infection, suggesting an important role for breast milk in protection of infants.
  • |*COVID-19[MESH]
  • |*Milk, Human[MESH]
  • |Antibodies, Viral[MESH]
  • |Breast Feeding[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]


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