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10.1371/journal.pone.0255132

http://scihub22266oqcxt.onion/10.1371/journal.pone.0255132
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34314458!8315514!34314458
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suck abstract from ncbi


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pmid34314458      PLoS+One 2021 ; 16 (7): e0255132
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  • Lower serum 25(OH)D levels associated with higher risk of COVID-19 infection in U S Black women #MMPMID34314458
  • Cozier YC; Castro-Webb N; Hochberg NS; Rosenberg L; Albert MA; Palmer JR
  • PLoS One 2021[]; 16 (7): e0255132 PMID34314458show ga
  • OBJECTIVE: Limited evidence suggests that higher levels of serum vitamin D (25(OH)D) protect against SARS-CoV-2 virus (COVID-19) infection. Black women commonly experience 25(OH)D insufficiency and are overrepresented among COVID-19 cases. We conducted a prospective analysis of serum 25(OH)D levels in relation to COVID-19 infection among participants in the Black Women's Health Study. METHODS: Since 1995, the Black Women's Health Study has followed 59,000 U.S. Black women through biennial mailed or online questionnaires. Over 13,000 study participants provided a blood sample in 2013-2017. 25(OH)D assays were performed in a certified national laboratory shortly after collection of the samples. In 2020, participants who had completed the online version of the 2019 biennial health questionnaire were invited to complete a supplemental online questionnaire assessing their experiences related to the COVID-19 pandemic, including whether they had been tested for COVID-19 infection and the result of the test. We used logistic regression analysis to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association of 25(OH)D level with COVID-19 positivity, adjusting for age, number of people living in the household, neighborhood socioeconomic status, and other potential confounders. RESULTS: Among 5,081 eligible participants whose blood sample had been assayed for 25(OH)D, 1,974 reported having had a COVID-19 test in 2020. Relative to women with 25(OH)D levels of 30 ng/mL (75 nmol/l) or more, multivariable-adjusted ORs for COVID-19 infection in women with levels of 20-29 ng/mL (50-72.5 nmol/l) and <20 ng/mL (<50 nmol/l) were, respectively, 1.48 (95% CI 0.95-2.30) and 1.69 (95% CI 1.04-2.72) (p trend 0.02). CONCLUSION: The present results suggest that U.S. Black women with lower levels of 25(OH)D are at increased risk of infection with COVID-19. Further work is needed to confirm these findings and determine the optimal level of 25(OH)D for a beneficial effect.
  • |Adult[MESH]
  • |Black or African American/*statistics & numerical data[MESH]
  • |COVID-19/*blood/*epidemiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Risk Factors[MESH]
  • |United States/epidemiology/ethnology[MESH]


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