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10.1172/jci.insight.147472 http://scihub22266oqcxt.onion/10.1172/jci.insight.147472 34314391!8492325!34314391     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (17): ä Nephropedia Template TP {{tp|p=34314391|t=2021. COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction |pdf=|usr=}}{{34314391}} gab.com Text COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34314391 #FOAvip Vascular injury has emerged as a complication contributing to morbidity in coronavirus disease 2019 (COVID-19). The glycosaminoglycan hyaluronan (HA) is a major component of the glycocalyx, a protective layer of glycoconjugates that lines the vascular lumen and regulates key endothelial cell functions. During critical illness, as in the case of sepsis, enzymes degrade the glycocalyx, releasing fragments with pathologic activities into circulation and thereby exacerbating disease. Here, we analyzed levels of circulating glycosaminoglycans in 46 patients with COVID-19 ranging from moderate to severe clinical severity and measured activities of corresponding degradative enzymes. This report provides evidence that the glycocalyx becomes significantly damaged in patients with COVID-19 and corresponds with severity of disease. Circulating HA fragments and hyaluronidase, 2 signatures of glycocalyx injury, strongly associate with sequential organ failure assessment scores and with increased inflammatory cytokine levels in patients with COVID-19. Pulmonary microvascular endothelial cells exposed to COVID-19 milieu show dysregulated HA biosynthesis and degradation, leading to production of pathological HA fragments that are released into circulation. Finally, we show that HA fragments present at high levels in COVID-19 patient plasma can directly induce endothelial barrier dysfunction in a ROCK- and CD44-dependent manner, indicating a role for HA in the vascular pathology of COVID-19. Twit Text FOAVip COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34314391 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34314391 #FOAvip English Wikipedia <ref>{{Cite pmid|34314391}}</ref> COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction #MMPMID34314391 Queisser KA; Mellema RA; Middleton EA; Portier I; Manne BK; Denorme F; Beswick EJ; Rondina MT; Campbell RA; Petrey AC JCI Insight 2021[Sep]; 6 (17): ä PMID34314391show ga Vascular injury has emerged as a complication contributing to morbidity in coronavirus disease 2019 (COVID-19). The glycosaminoglycan hyaluronan (HA) is a major component of the glycocalyx, a protective layer of glycoconjugates that lines the vascular lumen and regulates key endothelial cell functions. During critical illness, as in the case of sepsis, enzymes degrade the glycocalyx, releasing fragments with pathologic activities into circulation and thereby exacerbating disease. Here, we analyzed levels of circulating glycosaminoglycans in 46 patients with COVID-19 ranging from moderate to severe clinical severity and measured activities of corresponding degradative enzymes. This report provides evidence that the glycocalyx becomes significantly damaged in patients with COVID-19 and corresponds with severity of disease. Circulating HA fragments and hyaluronidase, 2 signatures of glycocalyx injury, strongly associate with sequential organ failure assessment scores and with increased inflammatory cytokine levels in patients with COVID-19. Pulmonary microvascular endothelial cells exposed to COVID-19 milieu show dysregulated HA biosynthesis and degradation, leading to production of pathological HA fragments that are released into circulation. Finally, we show that HA fragments present at high levels in COVID-19 patient plasma can directly induce endothelial barrier dysfunction in a ROCK- and CD44-dependent manner, indicating a role for HA in the vascular pathology of COVID-19. |Aged[MESH] |COVID-19/blood/*metabolism/pathology[MESH] |Cytokines/blood[MESH] |Endothelium, Vascular/*metabolism/pathology[MESH] |Female[MESH] |Glycocalyx/metabolism/pathology[MESH] |Humans[MESH] |Hyaluronan Receptors/metabolism[MESH] |Hyaluronic Acid/blood/*metabolism[MESH] |Hyaluronoglucosaminidase/blood/metabolism[MESH] |Male[MESH] |Middle Aged[MESH]COVID-19 generates hyaluronan fragments that directly induce endotheli(epmc).pdf DeepDyve Pubget Overpricing