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10.1007/s40618-021-01647-9 http://scihub22266oqcxt.onion/10.1007/s40618-021-01647-9 34312809!8312710!34312809     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Endocrinol+Invest 2022 ; 45 (1): 199-208 Nephropedia Template TP {{tp|p=34312809|t=2022. Non-thyroidal illness syndrome and SARS-CoV-2-associated multisystem inflammatory syndrome in children |pdf=|usr=}}{{34312809}} gab.com Text Non-thyroidal illness syndrome and SARS-CoV-2-associated multisystem inflammatory syndrome in children JO: J Endocrinol Invest http://www.kidney.de/pget.php?&tw=1&pmid=34312809 #FOAvip PURPOSE: COVID-19 disease may result in a severe multisystem inflammatory syndrome in children (MIS-C), which in turn may alter thyroid function (TF). We assessed TF in MIS-C, evaluating its impact on disease severity. METHODS: We retrospectively considered children admitted with MIS-C to a single pediatric hospital in Milan (November 2019-January 2021). Non-thyroidal illness syndrome (NTIS) was defined as any abnormality in TF tests (FT3, FT4, TSH) in the presence of critical illness and absence of a pre-existing hormonal abnormality. We devised a disease severity score by combining severity scores for each organ involved. Glucose and lipid profiles were also considered. A principal component analysis (PCA) was performed, to characterize the mutual association patterns between TF and disease severity. RESULTS: Of 26 (19 M/7F) patients, median age 10.7 (IQR 5.8-13.3) years, 23 (88.4%) presented with NTIS. A low FT3 level was noted in 15/23 (65.3%), while the other subjects had varying combinations of hormone abnormalities (8/23, 34.7%). Mutually correlated variables related to organ damage and inflammation were represented in the first dimension (PC1) of the PCA. FT3, FT4 and total cholesterol were positively correlated and characterized the second axis (PC2). The third axis (PC3) was characterized by the association of triglycerides, TyG index and HDL cholesterol. TF appeared to be related to lipemic and peripheral insulin resistance profiles. A possible association between catabolic components and severity score was also noted. CONCLUSIONS: A low FT3 level is common among MIS-C. TF may be useful to define the impact of MIS-C on children's health and help delineate long term follow-up management and prognosis. Twit Text FOAVip Non-thyroidal illness syndrome and SARS-CoV-2-associated multisystem inflammatory syndrome in children ????J Endocrinol Invest http://www.kidney.de/pget.php?&tw=1&pmid=34312809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34312809 #FOAvip English Wikipedia <ref>{{Cite pmid|34312809}}</ref> Non-thyroidal illness syndrome and SARS-CoV-2-associated multisystem inflammatory syndrome in children #MMPMID34312809 Calcaterra V; Biganzoli G; Dilillo D; Mannarino S; Fiori L; Pelizzo G; Zoia E; Fabiano V; Carlucci P; Camporesi A; Corti C; Mercurio G; Izzo F; Biganzoli E; Zuccotti G J Endocrinol Invest 2022[Jan]; 45 (1): 199-208 PMID34312809show ga PURPOSE: COVID-19 disease may result in a severe multisystem inflammatory syndrome in children (MIS-C), which in turn may alter thyroid function (TF). We assessed TF in MIS-C, evaluating its impact on disease severity. METHODS: We retrospectively considered children admitted with MIS-C to a single pediatric hospital in Milan (November 2019-January 2021). Non-thyroidal illness syndrome (NTIS) was defined as any abnormality in TF tests (FT3, FT4, TSH) in the presence of critical illness and absence of a pre-existing hormonal abnormality. We devised a disease severity score by combining severity scores for each organ involved. Glucose and lipid profiles were also considered. A principal component analysis (PCA) was performed, to characterize the mutual association patterns between TF and disease severity. RESULTS: Of 26 (19 M/7F) patients, median age 10.7 (IQR 5.8-13.3) years, 23 (88.4%) presented with NTIS. A low FT3 level was noted in 15/23 (65.3%), while the other subjects had varying combinations of hormone abnormalities (8/23, 34.7%). Mutually correlated variables related to organ damage and inflammation were represented in the first dimension (PC1) of the PCA. FT3, FT4 and total cholesterol were positively correlated and characterized the second axis (PC2). The third axis (PC3) was characterized by the association of triglycerides, TyG index and HDL cholesterol. TF appeared to be related to lipemic and peripheral insulin resistance profiles. A possible association between catabolic components and severity score was also noted. CONCLUSIONS: A low FT3 level is common among MIS-C. TF may be useful to define the impact of MIS-C on children's health and help delineate long term follow-up management and prognosis. |*SARS-CoV-2/physiology[MESH] |Adolescent[MESH] |COVID-19/*complications/epidemiology/physiopathology/therapy/virology[MESH] |Child[MESH] |Child, Preschool[MESH] |Euthyroid Sick Syndromes/*epidemiology/physiopathology/virology[MESH] |Female[MESH] |Humans[MESH] |Italy/epidemiology[MESH] |Male[MESH] |Prognosis[MESH] |Retrospective Studies[MESH] |Severity of Illness Index[MESH] |Systemic Inflammatory Response Syndrome/epidemiology/*virology[MESH] |Thyroid Gland/physiopathology/virology[MESH] |Thyrotropin/blood[MESH] |Thyroxine[MESH]Non-thyroidal illness syndrome and SARS-CoV-2-associated multisystem i(epmc).pdf DeepDyve Pubget Overpricing