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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 PLoS+One 2021 ; 16 (7): e0255096 Nephropedia Template TP
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Unified platform for genetic and serological detection of COVID-19 with single-molecule technology #MMPMID34310620
Furth N; Shilo S; Cohen N; Erez N; Fedyuk V; Schrager AM; Weinberger A; Dror AA; Zigron A; Shehadeh M; Sela E; Srouji S; Amit S; Levy I; Segal E; Dahan R; Jones D; Douek DC; Shema E
PLoS One 2021[]; 16 (7): e0255096 PMID34310620show ga
The COVID-19 pandemic raises the need for diverse diagnostic approaches to rapidly detect different stages of viral infection. The flexible and quantitative nature of single-molecule imaging technology renders it optimal for development of new diagnostic tools. Here we present a proof-of-concept for a single-molecule based, enzyme-free assay for detection of SARS-CoV-2. The unified platform we developed allows direct detection of the viral genetic material from patients' samples, as well as their immune response consisting of IgG and IgM antibodies. Thus, it establishes a platform for diagnostics of COVID-19, which could also be adjusted to diagnose additional pathogens.