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10.1371/journal.pone.0255096

http://scihub22266oqcxt.onion/10.1371/journal.pone.0255096
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34310620!8312974!34310620
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suck abstract from ncbi


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pmid34310620      PLoS+One 2021 ; 16 (7): e0255096
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  • Unified platform for genetic and serological detection of COVID-19 with single-molecule technology #MMPMID34310620
  • Furth N; Shilo S; Cohen N; Erez N; Fedyuk V; Schrager AM; Weinberger A; Dror AA; Zigron A; Shehadeh M; Sela E; Srouji S; Amit S; Levy I; Segal E; Dahan R; Jones D; Douek DC; Shema E
  • PLoS One 2021[]; 16 (7): e0255096 PMID34310620show ga
  • The COVID-19 pandemic raises the need for diverse diagnostic approaches to rapidly detect different stages of viral infection. The flexible and quantitative nature of single-molecule imaging technology renders it optimal for development of new diagnostic tools. Here we present a proof-of-concept for a single-molecule based, enzyme-free assay for detection of SARS-CoV-2. The unified platform we developed allows direct detection of the viral genetic material from patients' samples, as well as their immune response consisting of IgG and IgM antibodies. Thus, it establishes a platform for diagnostics of COVID-19, which could also be adjusted to diagnose additional pathogens.
  • |Antibodies, Viral/blood[MESH]
  • |Base Sequence[MESH]
  • |COVID-19 Nucleic Acid Testing/*methods/standards[MESH]
  • |COVID-19 Serological Testing/*methods/standards[MESH]
  • |COVID-19/blood/*diagnosis/immunology/virology[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Humans[MESH]
  • |Immune Sera/chemistry[MESH]
  • |Immunoglobulin G/blood[MESH]
  • |Immunoglobulin M/blood[MESH]
  • |Nasopharynx/virology[MESH]
  • |Polyproteins/blood/genetics[MESH]
  • |RNA, Viral/blood/genetics[MESH]
  • |SARS-CoV-2/genetics/*immunology[MESH]
  • |Sensitivity and Specificity[MESH]
  • |Single Molecule Imaging/instrumentation/*methods[MESH]


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  • suck abstract from ncbi

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