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10.1002/bies.202100087

http://scihub22266oqcxt.onion/10.1002/bies.202100087
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34309055!8390434!34309055
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suck abstract from ncbi


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pmid34309055      Bioessays 2021 ; 43 (9): e2100087
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  • Personalized health and the coronavirus vaccines-Do individual genetics matter? #MMPMID34309055
  • Valdes-Fernandez BN; Duconge J; Espino AM; Ruano G
  • Bioessays 2021[Sep]; 43 (9): e2100087 PMID34309055show ga
  • Vaccines represent preventative interventions amenable to immunogenetic prediction of how human variability will influence their safety and efficacy. The genetic polymorphism among individuals within any population can render possible that the immunity elicited by a vaccine is variable in length and strength. The same immune challenge (virus and/or vaccine) could provoke partial, complete or even failed protection for some individuals treated under the same conditions. We review genetic variants and mechanistic relationships among chemokines, chemokine receptors, interleukins, interferons, interferon receptors, toll-like receptors, histocompatibility antigens, various immunoglobulins and major histocompatibility complex antigens. These are the targets for variation among macrophages, dendritic cells, natural killer cells, T- and B-lymphocytes, and complement. The technology platforms (mRNA, viral vectors, proteins) utilized to produce vaccines against SARS-CoV-2 infections may each trigger genetically distinct immune reactogenic profiles. With DNA biobanking and immunoprofiling of recipients, global COVID-19 vaccinations could launch a new era of personalized healthcare.
  • |*COVID-19[MESH]
  • |*COVID-19 Vaccines[MESH]
  • |Biological Specimen Banks[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2[MESH]


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