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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Turk+J+Haematol 2021 ; 38 (4): 321-324 Nephropedia Template TP
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Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study #MMPMID34308605
Omma A; Erden A; Guven SC; Ates I; Kucuksahin O
Turk J Haematol 2021[Dec]; 38 (4): 321-324 PMID34308605show ga
OBJECTIVE: The aim of this study is to investigate post-COVID-19 antibody titers in patients who received convalescent plasma (CP) in addition to standard-of-care treatment. MATERIALS AND METHODS: Hospitalized COVID-19 patients who received CP in addition to standard care were retrospectively investigated. Patients who received CP with a recorded total COVID-19 antibody test result after treatment were included. From among hospitalized COVID-19 patients who received only standard care with a recorded total COVID-19 antibody test result, a control group matched for age, gender, and comorbidities was formed. Total COVID-19 antibody index levels were compared. RESULTS: Thirty-three CP recipients were enrolled in the study. The control group consisted of 34 age-, gender-, and comorbidity-matched standard-care patients. Median total COVID-19 antibody index levels were significantly reduced in the CP group. CONCLUSION: Although CP therapy may have benefits for disease outcome, its potential ability to hamper long-term immunity may be a problem.