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10.1155/2021/6689471 http://scihub22266oqcxt.onion/10.1155/2021/6689471 34307666!8266444!34307666     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2021 ; 2021 (ä): 6689471 Nephropedia Template TP {{tp|p=34307666|t=2021. Bioinformatics Analysis of Spike Proteins of Porcine Enteric Coronaviruses |pdf=|usr=}}{{34307666}} gab.com Text Bioinformatics Analysis of Spike Proteins of Porcine Enteric Coronaviruses JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=34307666 #FOAvip This article is aimed at analyzing the structure and function of the spike (S) proteins of porcine enteric coronaviruses, including transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea syndrome coronavirus (SADS-CoV) by applying bioinformatics methods. The physical and chemical properties, hydrophilicity and hydrophobicity, transmembrane region, signal peptide, phosphorylation and glycosylation sites, epitope, functional domains, and motifs of S proteins of porcine enteric coronaviruses were predicted and analyzed through online software. The results showed that S proteins of TGEV, PEDV, SADS-CoV, and PDCoV all contained transmembrane regions and signal peptide. TGEV S protein contained 139 phosphorylation sites, 24 glycosylation sites, and 53 epitopes. PEDV S protein had 143 phosphorylation sites, 22 glycosylation sites, and 51 epitopes. SADS-CoV S protein had 109 phosphorylation sites, 20 glycosylation sites, and 43 epitopes. PDCoV S protein had 124 phosphorylation sites, 18 glycosylation sites, and 52 epitopes. Moreover, TGEV, PEDV, and PDCoV S proteins all contained two functional domains and two motifs, spike_rec_binding and corona_S2. The corona_S2 consisted of S2 subunit heptad repeat 1 (HR1) and S2 subunit heptad repeat 2 (HR2) region profiles. Additionally, SADS-CoV S protein was predicted to contain only one functional domain, the corona_S2. This analysis of the biological functions of porcine enteric coronavirus spike proteins can provide a theoretical basis for the design of antiviral drugs. Twit Text FOAVip Bioinformatics Analysis of Spike Proteins of Porcine Enteric Coronaviruses ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=34307666 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34307666 #FOAvip English Wikipedia <ref>{{Cite pmid|34307666}}</ref> Bioinformatics Analysis of Spike Proteins of Porcine Enteric Coronaviruses #MMPMID34307666 Jia Y; Cao J; Wei Z Biomed Res Int 2021[]; 2021 (ä): 6689471 PMID34307666show ga This article is aimed at analyzing the structure and function of the spike (S) proteins of porcine enteric coronaviruses, including transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea syndrome coronavirus (SADS-CoV) by applying bioinformatics methods. The physical and chemical properties, hydrophilicity and hydrophobicity, transmembrane region, signal peptide, phosphorylation and glycosylation sites, epitope, functional domains, and motifs of S proteins of porcine enteric coronaviruses were predicted and analyzed through online software. The results showed that S proteins of TGEV, PEDV, SADS-CoV, and PDCoV all contained transmembrane regions and signal peptide. TGEV S protein contained 139 phosphorylation sites, 24 glycosylation sites, and 53 epitopes. PEDV S protein had 143 phosphorylation sites, 22 glycosylation sites, and 51 epitopes. SADS-CoV S protein had 109 phosphorylation sites, 20 glycosylation sites, and 43 epitopes. PDCoV S protein had 124 phosphorylation sites, 18 glycosylation sites, and 52 epitopes. Moreover, TGEV, PEDV, and PDCoV S proteins all contained two functional domains and two motifs, spike_rec_binding and corona_S2. The corona_S2 consisted of S2 subunit heptad repeat 1 (HR1) and S2 subunit heptad repeat 2 (HR2) region profiles. Additionally, SADS-CoV S protein was predicted to contain only one functional domain, the corona_S2. This analysis of the biological functions of porcine enteric coronavirus spike proteins can provide a theoretical basis for the design of antiviral drugs. |Alphacoronavirus/metabolism/pathogenicity[MESH] |Animals[MESH] |Computational Biology/methods[MESH] |Coronavirus Infections/*epidemiology[MESH] |Coronavirus/immunology/ultrastructure[MESH] |Databases, Genetic[MESH] |Deltacoronavirus/metabolism/pathogenicity[MESH] |Epitopes/immunology[MESH] |Porcine epidemic diarrhea virus/metabolism/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/*immunology/metabolism/*ultrastructure[MESH] |Swine Diseases/virology[MESH] |Swine/virology[MESH]Bioinformatics Analysis of Spike Proteins of Porcine Enteric Coronavir(epmc).pdf DeepDyve Pubget Overpricing