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10.3389/fimmu.2021.663912 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.663912 34305894!8297464!34305894     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 663912 Nephropedia Template TP {{tp|p=34305894|t=2021. The Spike of SARS-CoV-2: Uniqueness and Applications |pdf=|usr=}}{{34305894}} gab.com Text The Spike of SARS-CoV-2: Uniqueness and Applications JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34305894 #FOAvip The Spike (S) protein of the SARS-CoV-2 virus is critical for its ability to attach and fuse into the host cells, leading to infection, and transmission. In this review, we have initially performed a meta-analysis of keywords associated with the S protein to frame the outline of important research findings and directions related to it. Based on this outline, we have reviewed the structure, uniqueness, and origin of the S protein of SARS-CoV-2. Furthermore, the interactions of the Spike protein with host and its implications in COVID-19 pathogenesis, as well as drug and vaccine development, are discussed. We have also summarized the recent advances in detection methods using S protein-based RT-PCR, ELISA, point-of-care lateral flow immunoassay, and graphene-based field-effect transistor (FET) biosensors. Finally, we have also discussed the emerging Spike mutants and the efficacy of the Spike-based vaccines against those strains. Overall, we have covered most of the recent advances on the SARS-CoV-2 Spike protein and its possible implications in countering this virus. Twit Text FOAVip The Spike of SARS-CoV-2: Uniqueness and Applications ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34305894 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34305894 #FOAvip English Wikipedia <ref>{{Cite pmid|34305894}}</ref> The Spike of SARS-CoV-2: Uniqueness and Applications #MMPMID34305894 Kumavath R; Barh D; Andrade BS; Imchen M; Aburjaile FF; Ch A; Rodrigues DLN; Tiwari S; Alzahrani KJ; Goes-Neto A; Weener ME; Ghosh P; Azevedo V Front Immunol 2021[]; 12 (ä): 663912 PMID34305894show ga The Spike (S) protein of the SARS-CoV-2 virus is critical for its ability to attach and fuse into the host cells, leading to infection, and transmission. In this review, we have initially performed a meta-analysis of keywords associated with the S protein to frame the outline of important research findings and directions related to it. Based on this outline, we have reviewed the structure, uniqueness, and origin of the S protein of SARS-CoV-2. Furthermore, the interactions of the Spike protein with host and its implications in COVID-19 pathogenesis, as well as drug and vaccine development, are discussed. We have also summarized the recent advances in detection methods using S protein-based RT-PCR, ELISA, point-of-care lateral flow immunoassay, and graphene-based field-effect transistor (FET) biosensors. Finally, we have also discussed the emerging Spike mutants and the efficacy of the Spike-based vaccines against those strains. Overall, we have covered most of the recent advances on the SARS-CoV-2 Spike protein and its possible implications in countering this virus. |COVID-19 Drug Treatment[MESH] |COVID-19 Testing[MESH] |COVID-19 Vaccines/immunology[MESH] |COVID-19/diagnosis/prevention & control/virology[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Mutation[MESH] |SARS-CoV-2/genetics/immunology/isolation & purification/*metabolism[MESH] |Species Specificity[MESH]The Spike of SARS-CoV-2: Uniqueness and Applications (epmc).pdf DeepDyve Pubget Overpricing