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10.1007/s43450-021-00162-5 http://scihub22266oqcxt.onion/10.1007/s43450-021-00162-5 34305198!8294293!34305198     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rev+Bras+Farmacogn 2021 ; 31 (5): 658-666 Nephropedia Template TP {{tp|p=34305198|t=2021. Flavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-2 Replication |pdf=|usr=}}{{34305198}} gab.com Text Flavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-2 Replication JO: Rev Bras Farmacogn http://www.kidney.de/pget.php?&tw=1&pmid=34305198 #FOAvip The novel coronavirus SARS-CoV-2 has been affecting the world, causing severe pneumonia and acute respiratory syndrome, leading people to death. Therefore, the search for anti-SARS-CoV-2 compounds is pivotal for public health. Natural products may present sources of bioactive compounds; among them, flavonoids are known in literature for their antiviral activity. Siparuna species are used in Brazilian folk medicine for the treatment of colds and flu. This work describes the isolation of 3,3',4'-tri-O-methyl-quercetin, 3,7,3',4'-tetra-O-methyl-quercetin (retusin), and 3,7-di-O-methyl-kaempferol (kumatakenin) from the dichloromethane extract of leaves of Siparuna cristata (Poepp. & Endl.) A.DC., Siparunaceae, using high-speed countercurrent chromatography in addition to the investigation of their inhibitory effect against SARS-CoV-2 viral replication. Retusin and kumatakenin inhibited SARS-CoV-2 replication in Vero E6 and Calu-3 cells, with a selective index greater than lopinavir/ritonavir and chloroquine, used as control. Flavonoids and their derivatives may stand for target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s43450-021-00162-5. Twit Text FOAVip Flavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-2 Replication ????Rev Bras Farmacogn http://www.kidney.de/pget.php?&tw=1&pmid=34305198 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34305198 #FOAvip English Wikipedia <ref>{{Cite pmid|34305198}}</ref> Flavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-2 Replication #MMPMID34305198 Leal CM; Leitao SG; Sausset R; Mendonca SC; Nascimento PHA; de Araujo R Cheohen CF; Esteves MEA; Leal da Silva M; Gondim TS; Monteiro MES; Tucci AR; Fintelman-Rodrigues N; Siqueira MM; Miranda MD; Costa FN; Simas RC; Leitao GG Rev Bras Farmacogn 2021[]; 31 (5): 658-666 PMID34305198show ga The novel coronavirus SARS-CoV-2 has been affecting the world, causing severe pneumonia and acute respiratory syndrome, leading people to death. Therefore, the search for anti-SARS-CoV-2 compounds is pivotal for public health. Natural products may present sources of bioactive compounds; among them, flavonoids are known in literature for their antiviral activity. Siparuna species are used in Brazilian folk medicine for the treatment of colds and flu. This work describes the isolation of 3,3',4'-tri-O-methyl-quercetin, 3,7,3',4'-tetra-O-methyl-quercetin (retusin), and 3,7-di-O-methyl-kaempferol (kumatakenin) from the dichloromethane extract of leaves of Siparuna cristata (Poepp. & Endl.) A.DC., Siparunaceae, using high-speed countercurrent chromatography in addition to the investigation of their inhibitory effect against SARS-CoV-2 viral replication. Retusin and kumatakenin inhibited SARS-CoV-2 replication in Vero E6 and Calu-3 cells, with a selective index greater than lopinavir/ritonavir and chloroquine, used as control. Flavonoids and their derivatives may stand for target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s43450-021-00162-5. äFlavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-(epmc).pdf DeepDyve Pubget Overpricing