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10.12659/MSM.934077 http://scihub22266oqcxt.onion/10.12659/MSM.934077 34305135!8323472!34305135     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Sci+Monit 2021 ; 27 (ä): e934077 Nephropedia Template TP {{tp|p=34305135|t=2021. Editorial: Targets for Disease-Modifying Therapies in Alzheimer s Disease, Including Amyloid beta and Tau Protein |pdf=|usr=}}{{34305135}} gab.com Text Editorial: Targets for Disease-Modifying Therapies in Alzheimer s Disease, Including Amyloid beta and Tau Protein JO: Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=34305135 #FOAvip Current treatments for patients with Alzheimer's disease aim to improve behavioral, cognitive, and non-cognitive symptoms. There have been no new drug approvals for preventing or treating Alzheimer's disease for more than two decades. Drug development in Alzheimer's disease aims to identify disease-modifying therapies that will delay or slow the clinical course of this disease. More than 50% of the current Alzheimer's disease drug pipeline now involves immunotherapies or oral small molecule agents. The most promising disease-modifying drug targets are amyloid ss and tau protein. In June 2021, aducanumab, a humanized recombinant monoclonal antibody to amyloid ss, was the first potential disease-modifying therapy approved by the US Food and Drug Administration (FDA) to treat Alzheimer's disease and mild cognitive impairment. Accelerated approval of aducanumab was based on the results of only one of two phase 3 clinical trials. Several clinical trials of targeted disease-modifying immunotherapies to the tau protein and amyloid ss that commenced before the current COVID-19 pandemic have been delayed. This Editorial aims to provide an update on past, present, and future disease-modifying therapies in Alzheimer's disease, including targeted therapies for amyloid ss and tau protein. Twit Text FOAVip Editorial: Targets for Disease-Modifying Therapies in Alzheimer s Disease, Including Amyloid beta and Tau Protein ????Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=34305135 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34305135 #FOAvip English Wikipedia <ref>{{Cite pmid|34305135}}</ref> Editorial: Targets for Disease-Modifying Therapies in Alzheimer s Disease, Including Amyloid beta and Tau Protein #MMPMID34305135 Parums DV Med Sci Monit 2021[Jul]; 27 (ä): e934077 PMID34305135show ga Current treatments for patients with Alzheimer's disease aim to improve behavioral, cognitive, and non-cognitive symptoms. There have been no new drug approvals for preventing or treating Alzheimer's disease for more than two decades. Drug development in Alzheimer's disease aims to identify disease-modifying therapies that will delay or slow the clinical course of this disease. More than 50% of the current Alzheimer's disease drug pipeline now involves immunotherapies or oral small molecule agents. The most promising disease-modifying drug targets are amyloid ss and tau protein. In June 2021, aducanumab, a humanized recombinant monoclonal antibody to amyloid ss, was the first potential disease-modifying therapy approved by the US Food and Drug Administration (FDA) to treat Alzheimer's disease and mild cognitive impairment. Accelerated approval of aducanumab was based on the results of only one of two phase 3 clinical trials. Several clinical trials of targeted disease-modifying immunotherapies to the tau protein and amyloid ss that commenced before the current COVID-19 pandemic have been delayed. This Editorial aims to provide an update on past, present, and future disease-modifying therapies in Alzheimer's disease, including targeted therapies for amyloid ss and tau protein. |Alzheimer Disease/*drug therapy/*metabolism[MESH] |Amyloid beta-Peptides/*metabolism[MESH] |Antibodies, Monoclonal, Humanized/therapeutic use[MESH] |Cognitive Dysfunction/drug therapy/immunology[MESH] |Humans[MESH] |Immunotherapy/methods/trends[MESH] |Tauopathies/drug therapy[MESH]Editorial: Targets for Disease-Modifying Therapies in Alzheimer s Dise(epmc).pdf DeepDyve Pubget Overpricing