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10.1016/j.jcv.2021.104913 http://scihub22266oqcxt.onion/10.1016/j.jcv.2021.104913 34304090!8285219!34304090     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Virol 2021 ; 142 (ä): 104913 Nephropedia Template TP {{tp|p=34304090|t=2021. Performance of saliva as a specimen to detect SARS-CoV-2 |pdf=|usr=}}{{34304090}} gab.com Text Performance of saliva as a specimen to detect SARS-CoV-2 JO: J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=34304090 #FOAvip Massive testing to detect SARS-CoV-2 is an imperious need in times of epidemic but also presents challenges in terms of its concretization. The use of saliva as an alternative to nasopharyngeal swabs (NPS) has advantages, being more friendly to the patient and not requiring trained health workers, so much needed in other functions. This study used a total of 452 dual samples (saliva and NPS) of patients suspected of having COVID-19 to compare results obtained for the different specimens when using RT-PCR of RNA extracted from NPS and saliva, as well as saliva directly without RNA extraction. SARS-CoV-2 was not detected in 13 saliva (direct) of the 80 positive NPS samples and in 16 saliva (RNA) of a total of 76 NPS positive samples. Sensitivity of detection of viral genes ORF1ab, E and N in saliva is affected differently and detection of these genes in saliva samples presents great variability when NPS samples present Ct-values above approximately 20, with sensitivities ranging from 76.3% to 86.3%. On average an increase in 7.3 Ct-values (average standard deviation of 4.78) is observed in saliva samples when compared to NPS. The use of this specimen should be carefully considered due to the false negative rate and the system used for detection may be also very relevant since the different viral genes are affected differently in terms of detection sensitivity using saliva. Twit Text FOAVip Performance of saliva as a specimen to detect SARS-CoV-2 ????J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=34304090 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34304090 #FOAvip English Wikipedia <ref>{{Cite pmid|34304090}}</ref> Performance of saliva as a specimen to detect SARS-CoV-2 #MMPMID34304090 Fernandes PADC; Ferreira FADC; Morais OM; Ramos CMT; Fernandes EMR; Rocha SAAD; Rocha RJA; Monteiro VJP; Vilar PSG; Romao AM; Alves MRA J Clin Virol 2021[Sep]; 142 (ä): 104913 PMID34304090show ga Massive testing to detect SARS-CoV-2 is an imperious need in times of epidemic but also presents challenges in terms of its concretization. The use of saliva as an alternative to nasopharyngeal swabs (NPS) has advantages, being more friendly to the patient and not requiring trained health workers, so much needed in other functions. This study used a total of 452 dual samples (saliva and NPS) of patients suspected of having COVID-19 to compare results obtained for the different specimens when using RT-PCR of RNA extracted from NPS and saliva, as well as saliva directly without RNA extraction. SARS-CoV-2 was not detected in 13 saliva (direct) of the 80 positive NPS samples and in 16 saliva (RNA) of a total of 76 NPS positive samples. Sensitivity of detection of viral genes ORF1ab, E and N in saliva is affected differently and detection of these genes in saliva samples presents great variability when NPS samples present Ct-values above approximately 20, with sensitivities ranging from 76.3% to 86.3%. On average an increase in 7.3 Ct-values (average standard deviation of 4.78) is observed in saliva samples when compared to NPS. The use of this specimen should be carefully considered due to the false negative rate and the system used for detection may be also very relevant since the different viral genes are affected differently in terms of detection sensitivity using saliva. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Humans[MESH] |Nasopharynx[MESH] |RNA, Viral/genetics[MESH] |Saliva[MESH]Performance of saliva as a specimen to detect SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing