Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.ejphar.2021.174374 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2021.174374 34303662!8295491!34303662     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2021 ; 908 (ä): 174374 Nephropedia Template TP {{tp|p=34303662|t=2021. SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway |pdf=|usr=}}{{34303662}} gab.com Text SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34303662 #FOAvip The efficacy of corticosteroids and its use for the treatment of SARS-CoV-2 infections is controversial. In this study, using data sets of SARS-CoV-2 infected lung tissues and nasopharyngeal swabs, as well as in vitro experiments, we show that SARS-CoV-2 infection significantly downregulates DUSP1 expression. This downregulation of DUSP1 could be the mechanism regulating the enhanced activation of MAPK pathway as well as the reported steroid resistance in SARS-CoV-2 infection. Moreover, chloroquine, an off labeled COVID-19 drug is able to induce DUSP1 and attenuate MAPK pathway; and is expected to improve sensitivity to steroid treatment. However, further mechanistic studies are required to confirm this effect. Twit Text FOAVip SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34303662 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34303662 #FOAvip English Wikipedia <ref>{{Cite pmid|34303662}}</ref> SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway #MMPMID34303662 Saheb Sharif-Askari F; Saheb Sharif-Askari N; Goel S; Hafezi S; Assiri R; Al-Muhsen S; Hamid Q; Halwani R Eur J Pharmacol 2021[Oct]; 908 (ä): 174374 PMID34303662show ga The efficacy of corticosteroids and its use for the treatment of SARS-CoV-2 infections is controversial. In this study, using data sets of SARS-CoV-2 infected lung tissues and nasopharyngeal swabs, as well as in vitro experiments, we show that SARS-CoV-2 infection significantly downregulates DUSP1 expression. This downregulation of DUSP1 could be the mechanism regulating the enhanced activation of MAPK pathway as well as the reported steroid resistance in SARS-CoV-2 infection. Moreover, chloroquine, an off labeled COVID-19 drug is able to induce DUSP1 and attenuate MAPK pathway; and is expected to improve sensitivity to steroid treatment. However, further mechanistic studies are required to confirm this effect. |*COVID-19 Drug Treatment[MESH] |Adult[MESH] |Aged[MESH] |COVID-19/pathology/virology[MESH] |Case-Control Studies[MESH] |Cells, Cultured[MESH] |Chloroquine/*pharmacology/therapeutic use[MESH] |Datasets as Topic[MESH] |Down-Regulation/drug effects[MESH] |Drug Resistance/drug effects/genetics[MESH] |Drug Synergism[MESH] |Dual Specificity Phosphatase 1/*genetics/metabolism[MESH] |Fibroblasts[MESH] |Glucocorticoids/*pharmacology/therapeutic use[MESH] |Healthy Volunteers[MESH] |Humans[MESH] |Lung/cytology/pathology[MESH] |MAP Kinase Signaling System/drug effects/genetics[MESH] |Middle Aged[MESH] |Nasopharynx/virology[MESH] |Off-Label Use[MESH] |Primary Cell Culture[MESH] |SARS-CoV-2/isolation & purification/pathogenicity[MESH]SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 (epmc).pdf DeepDyve Pubget Overpricing