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10.1016/j.ijid.2021.07.041

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.07.041
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suck abstract from ncbi


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pmid34302964      Int+J+Infect+Dis 2021 ; 110 (ä): 98-104
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  • BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals #MMPMID34302964
  • Kumar NP; Padmapriyadarsini C; Rajamanickam A; Bhavani PK; Nancy A; Jeyadeepa B; Selvaraj N; Ashokan D; Renji RM; Venkataramani V; Tripathy S; Babu S
  • Int J Infect Dis 2021[Sep]; 110 (ä): 98-104 PMID34302964show ga
  • OBJECTIVE: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell (DC) subsets is not well characterized. METHODS: We investigated the impact of BCG vaccination on the frequencies of DC subsets and type I and III interferons (IFNs) using whole blood and plasma samples in a group of elderly individuals (age 60-80 years) at one-month post-vaccination as part of our clinical study to examine the effect of BCG on COVID-19. RESULTS: Our results demonstrate that BCG vaccination induced enhanced frequencies of plasmacytoid DC (pDC) and myeloid DC (mDC). BCG vaccination also induced diminished plasma levels of type I IFNs, IFNalpha and IFNbeta but increased levels of type III IFNs, IL-28A and IL-29. CONCLUSIONS: Thus, BCG vaccination was associated with enhanced DC subsets and IL-28A/IL-29 in elderly individuals, suggesting its ability to induce non-specific innate immune responses.
  • |*BCG Vaccine[MESH]
  • |*COVID-19[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Dendritic Cells[MESH]
  • |Humans[MESH]
  • |Interferon Lambda[MESH]
  • |Interferon-alpha[MESH]
  • |Interferons[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2[MESH]


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