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10.1016/j.ijid.2021.07.043

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.07.043
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34302961!8295062!34302961
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suck abstract from ncbi


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pmid34302961      Int+J+Infect+Dis 2021 ; 110 (ä): 135-140
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  • Performance of a SARS-CoV-2 antigen rapid immunoassay in patients admitted to the emergency department #MMPMID34302961
  • Leli C; Di Matteo L; Gotta F; Cornaglia E; Vay D; Megna I; Pensato RE; Boverio R; Rocchetti A
  • Int J Infect Dis 2021[Sep]; 110 (ä): 135-140 PMID34302961show ga
  • OBJECTIVES: Given the ongoing pandemic emergency, there is a need to identify SARS CoV-2 infection in various community settings. Rapid antigen testing is spreading worldwide, but diagnostic accuracy is extremely variable. Our study compared a microfluidic rapid antigen test with a reference molecular assay in patients admitted to the emergency department (ED) of a general hospital from October 2020 to January 2021. METHODS: Nasopharyngeal swabs collected in patients with suspected COVID-19 and in patients with no symptoms suggesting COVID-19, but requiring hospitalization, were obtained. RESULTS: 792 patients of median age 71 years were included. With a prevalence of 21%, the results showed: 68.7% (95% confidence interval [CI]: 60.9-75.5) sensitivity; 95.2% (95% CI: 93.1-96.7) specificity; 79.2% (95% CI: 71.4-85.3) positive predictive value (PPV); 91.9% (95% CI: 89.5-93.9) negative predictive value; 3.8 (95% CI: 2.7-5.3) positive likelihood ratio (LR+); and 0.09 (95% CI: 0.07-0.1) negative likelihood ratio (LR-). In the symptomatic subgroup, sensitivity increased to 81% (95% CI: 70.3-88.6) and PPV to 96.9% (95% CI: 88.5-99.5), along with an LR+ of 32 (95% CI: 8.2-125.4). CONCLUSIONS: The new rapid antigen test showed an overall excellent diagnostic performance in a challenging situation, such as that of an ED during the COVID-19 emergency.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Aged[MESH]
  • |Emergency Service, Hospital[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Immunoassay[MESH]


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