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10.1093/gbe/evab173 http://scihub22266oqcxt.onion/10.1093/gbe/evab173 34302465!8369073!34302465     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34302465&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Genome+Biol+Evol 2021 ; 13 (8): ? Nephropedia Template TP {{tp|p=34302465|t=2021. Ancient Adaptative Evolution of ACE2 in East Asians |pdf=|usr=}}{{34302465}} gab.com Text Ancient Adaptative Evolution of ACE2 in East Asians JO: Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=34302465 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been posing an unprecedented challenge to global public health. SARS-CoV-2 and several other coronaviruses utilize angiotensin-converting enzyme 2 (ACE2) as their entry receptors. The ACE2 gene has been found to experience episodic positive selection across mammals. However, much remains unknown about how the ACE2 gene evolved in human populations. Here, we use population genetics approaches to investigate the evolution of the ACE2 gene in 26 human populations sampled globally. We find the ACE2 gene exhibits an extremely low nucleotide diversity in the East Asian populations. Strong signals of selective sweep are detected in the East Asian populations, but not in the other human populations. The selective sweep in ACE2 is estimated to begin in East Asian populations approximately 23,600 years ago. Our study provides novel insights into the evolution of the ACE2 gene within human populations. Twit Text FOAVip Ancient Adaptative Evolution of ACE2 in East Asians ????Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=34302465 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34302465 #FOAvip English Wikipedia <ref>{{Cite pmid|34302465}}</ref> Ancient Adaptative Evolution of ACE2 in East Asians #MMPMID34302465 Wang W; Han GZ Genome Biol Evol 2021[Aug]; 13 (8): ? PMID34302465show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been posing an unprecedented challenge to global public health. SARS-CoV-2 and several other coronaviruses utilize angiotensin-converting enzyme 2 (ACE2) as their entry receptors. The ACE2 gene has been found to experience episodic positive selection across mammals. However, much remains unknown about how the ACE2 gene evolved in human populations. Here, we use population genetics approaches to investigate the evolution of the ACE2 gene in 26 human populations sampled globally. We find the ACE2 gene exhibits an extremely low nucleotide diversity in the East Asian populations. Strong signals of selective sweep are detected in the East Asian populations, but not in the other human populations. The selective sweep in ACE2 is estimated to begin in East Asian populations approximately 23,600 years ago. Our study provides novel insights into the evolution of the ACE2 gene within human populations. |*Evolution, Molecular[MESH] |Adaptation, Physiological[MESH] |Angiotensin-Converting Enzyme 2/*genetics[MESH] |Asian People/*genetics[MESH] |DNA, Ancient[MESH] |Haplotypes[MESH] |Humans[MESH]Ancient Adaptative Evolution of ACE2 in East Asians (epmc).pdf DeepDyve Pubget Overpricing