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10.1093/ajcp/aqab081

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34302455!8336596!34302455
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suck abstract from ncbi


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pmid34302455      Am+J+Clin+Pathol 2021 ; 156 (3): 370-380
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  • Use, Safety Assessment, and Implementation of Two Point-of-Care Tests for COVID-19 Testing #MMPMID34302455
  • Hahn M; Olsen A; Stokes K; Fowler RC; Gu R; Semple-Lytch S; DeVito A; Kurpiel P; Hughes S; Rakeman JL
  • Am J Clin Pathol 2021[Aug]; 156 (3): 370-380 PMID34302455show ga
  • OBJECTIVES: The Abbot ID NOW COVID-19 assay and Quidel Sofia 2 SARS Antigen FIA are point-of-care assays that offer rapid testing for severe acute respiratory syndrome coronavirus 2 viral RNA and nucleocapsid protein, respectively. Given the utility of these devices in the field, we investigated the feasibility and safety of using the ID NOW and Sofia assays in the public health response to the coronavirus disease 2019 pandemic and in future public health emergencies. METHODS: A combination of utilization and contamination testing in addition to a review of instrument workflows was conducted. RESULTS: Utilization testing demonstrated that both tests are intuitive, associated with high user test success (85%) in our study, and could be implemented by staff after minimal training. Contamination tests revealed potential biosafety concerns due to the open design of the ID NOW instrument and the transfer mechanisms with the Sofia. When comparing the workflow of the ID NOW and the Sofia, we found that the ID NOW was more user-friendly and that the transfer technology reduces the chance of contamination. CONCLUSIONS: The ID NOW, Sofia, and other emerging point-of-care tests should be used only after careful consideration of testing workflow, biosafety risk mitigations, and appropriate staff training.
  • |*COVID-19 Testing[MESH]
  • |*Pandemics[MESH]
  • |*Point-of-Care Testing[MESH]
  • |Antigens, Viral/*analysis[MESH]
  • |COVID-19/*diagnosis/epidemiology/virology[MESH]
  • |Containment of Biohazards[MESH]
  • |Equipment Safety[MESH]
  • |Feasibility Studies[MESH]
  • |Humans[MESH]
  • |Risk Assessment[MESH]


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