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10.1007/s13312-021-2329-9

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suck abstract from ncbi


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pmid34302327      Indian+Pediatr 2021 ; 58 (10): 951-954
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  • Comparison of Clinical Features and Outcome of Dengue Fever and Multisystem Inflammatory Syndrome in Children Associated With COVID-19 (MIS-C) #MMPMID34302327
  • Dhooria GS; Kakkar S; Pooni PA; Bhat D; Bhargava S; Arora K; Gill K; Goel N
  • Indian Pediatr 2021[Oct]; 58 (10): 951-954 PMID34302327show ga
  • OBJECTIVE: To identify clinical and laboratory features that differentiate dengue fever patients from MIS-C patients and determine their outcomes. METHODS: This comparative cross-sectional study was done at a tertiary care teaching institute. We enrolled all hospitalized children aged 1 month - 18 years and diagnosed with either MIS-C and/or dengue fever according to WHO criteria between June and December, 2020. Clinical and laboratory features and outcomes were recorded on a structured proforma. RESULTS: During the study period 34 cases of MIS-C and 83 cases of Dengue fever were enrolled. Mean age of MIS-C cases (male, 86.3%) was 7.89 (4.61) years. MIS-C with shock was seen in 15 cases (44%), MIS-C without shock in 17 cases (50%) and Kawasaki disease-like presentation in 2 cases (6%). Patients of MIS-C were younger as compared to dengue fever (P=0.002). Abdominal pain and erythematous rash were more common in dengue fever. Of the inflammatory markers, mean C reactive protein was higher in MIS-C patients [100.2 (85.1) vs 16.9 (29.3) mg/dL] (P<0.001). In contrast, serum ferritin levels were higher in dengue fever patients (P=0.03). Mean hospital stay (patient days) was longer in MIS- C compared to dengue fever (8.6 vs 6.5 days; P=0.014). CONCLUSION: Clinical and laboratory features can give important clues to differentiate dengue fever and MIS-C and help initiate specific treatment.
  • |*COVID-19/complications[MESH]
  • |*Dengue/diagnosis/epidemiology[MESH]
  • |Child[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |SARS-CoV-2[MESH]


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