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10.1007/s00216-021-03561-8 http://scihub22266oqcxt.onion/10.1007/s00216-021-03561-8 34302183!8302467!34302183     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Anal+Bioanal+Chem 2021 ; 413 (23): 5811-5820 Nephropedia Template TP {{tp|p=34302183|t=2021. Quantitative HPLC-MS/MS determination of Nuc, the active metabolite of remdesivir, and its pharmacokinetics in rat |pdf=|usr=}}{{34302183}} gab.com Text Quantitative HPLC-MS/MS determination of Nuc, the active metabolite of remdesivir, and its pharmacokinetics in rat JO: Anal Bioanal Chem http://www.kidney.de/pget.php?&tw=1&pmid=34302183 #FOAvip Remdesivir is a nucleotide analog prodrug that has received much attention since the outbreak of the COVID-19 pandemic in December 2019. GS-441524 (Nuc) is the active metabolite of remdesivir and plays a pivotal role in the clinical treatment of COVID-19. Here, a robust HPLC-MS/MS method was developed to determine Nuc concentrations in rat plasma samples after a one-step protein precipitation process. Chromatographic separation was accomplished on Waters XBrige C(18) column (50 x 2.1 mm, 3.5 mum) under gradient elution conditions. Multiple reaction monitoring transitions in electrospray positive ion mode were m/z 292.2 --> 163.2 for Nuc and 237.1 --> 194.1 for the internal standard (carbamazepine). The quantitative analysis method was fully validated in line with the United States Food and Drug Administration guidelines. The linearity, accuracy and precision, matrix effect, recovery, and stability results met the requirements of the guidelines. Uncertainty of measurement and incurred sample reanalysis were analyzed to further ensure the robustness and reproducibility of the method. This optimized method was successfully applied in a rat pharmacokinetics study of remdesivir (intravenously administration, 5 mg kg(-1)). The method can act as a basis for further pharmacokinetic and clinical efficacy investigations in patients with COVID-19. Graphical abstract. Twit Text FOAVip Quantitative HPLC-MS/MS determination of Nuc, the active metabolite of remdesivir, and its pharmacokinetics in rat ????Anal Bioanal Chem http://www.kidney.de/pget.php?&tw=1&pmid=34302183 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34302183 #FOAvip English Wikipedia <ref>{{Cite pmid|34302183}}</ref> Quantitative HPLC-MS/MS determination of Nuc, the active metabolite of remdesivir, and its pharmacokinetics in rat #MMPMID34302183 Du P; Wang G; Yang S; Li P; Liu L Anal Bioanal Chem 2021[Sep]; 413 (23): 5811-5820 PMID34302183show ga Remdesivir is a nucleotide analog prodrug that has received much attention since the outbreak of the COVID-19 pandemic in December 2019. GS-441524 (Nuc) is the active metabolite of remdesivir and plays a pivotal role in the clinical treatment of COVID-19. Here, a robust HPLC-MS/MS method was developed to determine Nuc concentrations in rat plasma samples after a one-step protein precipitation process. Chromatographic separation was accomplished on Waters XBrige C(18) column (50 x 2.1 mm, 3.5 mum) under gradient elution conditions. Multiple reaction monitoring transitions in electrospray positive ion mode were m/z 292.2 --> 163.2 for Nuc and 237.1 --> 194.1 for the internal standard (carbamazepine). The quantitative analysis method was fully validated in line with the United States Food and Drug Administration guidelines. The linearity, accuracy and precision, matrix effect, recovery, and stability results met the requirements of the guidelines. Uncertainty of measurement and incurred sample reanalysis were analyzed to further ensure the robustness and reproducibility of the method. This optimized method was successfully applied in a rat pharmacokinetics study of remdesivir (intravenously administration, 5 mg kg(-1)). The method can act as a basis for further pharmacokinetic and clinical efficacy investigations in patients with COVID-19. Graphical abstract. |Adenosine Monophosphate/*analogs & derivatives/blood/pharmacokinetics/standards[MESH] |Adenosine/*analogs & derivatives/blood/pharmacokinetics/standards[MESH] |Alanine/*analogs & derivatives/blood/pharmacokinetics/standards[MESH] |Animals[MESH] |Antiviral Agents/*blood/pharmacokinetics/standards[MESH] |Chromatography, High Pressure Liquid/*methods[MESH] |Limit of Detection[MESH] |Male[MESH] |Quality Control[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Reference Standards[MESH] |Reproducibility of Results[MESH]Quantitative HPLC-MS/MS determination of Nuc, the active metabolite of(epmc).pdf DeepDyve Pubget Overpricing