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10.1101/gad.348660.121 http://scihub22266oqcxt.onion/10.1101/gad.348660.121 34301768!8336889!34301768     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+Dev 2021 ; 35 (15-16): 1123-1141 Nephropedia Template TP {{tp|p=34301768|t=2021. Nopp140-chaperoned 2 -O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity |pdf=|usr=}}{{34301768}} gab.com Text Nopp140-chaperoned 2 -O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=34301768 #FOAvip Spliceosomal small nuclear RNAs (snRNAs) are modified by small Cajal body (CB)-specific ribonucleoproteins (scaRNPs) to ensure snRNP biogenesis and pre-mRNA splicing. However, the function and subcellular site of snRNA modification are largely unknown. We show that CB localization of the protein Nopp140 is essential for concentration of scaRNPs in that nuclear condensate; and that phosphorylation by casein kinase 2 (CK2) at approximately 80 serines targets Nopp140 to CBs. Transiting through CBs, snRNAs are apparently modified by scaRNPs. Indeed, Nopp140 knockdown-mediated release of scaRNPs from CBs severely compromises 2'-O-methylation of spliceosomal snRNAs, identifying CBs as the site of scaRNP catalysis. Additionally, alternative splicing patterns change indicating that these modifications in U1, U2, U5, and U12 snRNAs safeguard splicing fidelity. Given the importance of CK2 in this pathway, compromised splicing could underlie the mode of action of small molecule CK2 inhibitors currently considered for therapy in cholangiocarcinoma, hematological malignancies, and COVID-19. Twit Text FOAVip Nopp140-chaperoned 2 -O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=34301768 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34301768 #FOAvip English Wikipedia <ref>{{Cite pmid|34301768}}</ref> Nopp140-chaperoned 2 -O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity #MMPMID34301768 Bizarro J; Deryusheva S; Wacheul L; Gupta V; Ernst FGM; Lafontaine DLJ; Gall JG; Meier UT Genes Dev 2021[Aug]; 35 (15-16): 1123-1141 PMID34301768show ga Spliceosomal small nuclear RNAs (snRNAs) are modified by small Cajal body (CB)-specific ribonucleoproteins (scaRNPs) to ensure snRNP biogenesis and pre-mRNA splicing. However, the function and subcellular site of snRNA modification are largely unknown. We show that CB localization of the protein Nopp140 is essential for concentration of scaRNPs in that nuclear condensate; and that phosphorylation by casein kinase 2 (CK2) at approximately 80 serines targets Nopp140 to CBs. Transiting through CBs, snRNAs are apparently modified by scaRNPs. Indeed, Nopp140 knockdown-mediated release of scaRNPs from CBs severely compromises 2'-O-methylation of spliceosomal snRNAs, identifying CBs as the site of scaRNP catalysis. Additionally, alternative splicing patterns change indicating that these modifications in U1, U2, U5, and U12 snRNAs safeguard splicing fidelity. Given the importance of CK2 in this pathway, compromised splicing could underlie the mode of action of small molecule CK2 inhibitors currently considered for therapy in cholangiocarcinoma, hematological malignancies, and COVID-19. |*Methylation[MESH] |*RNA Splicing[MESH] |COVID-19 Drug Treatment[MESH] |Casein Kinase II/antagonists & inhibitors/metabolism[MESH] |Cholangiocarcinoma/drug therapy[MESH] |Hematologic Neoplasms/drug therapy[MESH] |Humans[MESH] |Interstitial Cells of Cajal/*metabolism[MESH] |Nuclear Proteins/*metabolism[MESH] |Phosphoproteins/*metabolism[MESH] |Phosphorylation[MESH] |RNA, Small Nuclear/chemistry/*metabolism[MESH] |Ribonucleoproteins/metabolism[MESH]Nopp140-chaperoned 2 -O-methylation of small nuclear RNAs in Cajal bod(epmc).pdf DeepDyve Pubget Overpricing