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10.3390/s21144814 http://scihub22266oqcxt.onion/10.3390/s21144814 34300555!8309820!34300555     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sensors+(Basel) 2021 ; 21 (14): ä Nephropedia Template TP {{tp|p=34300555|t=2021. Rapid and Sensitive Inhibitor Screening Using Magnetically Modulated Biosensors |pdf=|usr=}}{{34300555}} gab.com Text Rapid and Sensitive Inhibitor Screening Using Magnetically Modulated Biosensors JO: Sensors (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34300555 #FOAvip Inhibitor screening is an important tool for drug development, especially during the COVID-19 pandemic. The most used in vitro inhibitor screening tool is an enzyme-linked immunosorbent assay (ELISA). However, ELISA-based inhibitor screening is time consuming and has a limited dynamic range. Using fluorescently and magnetically modulated biosensors (MMB), we developed a rapid and sensitive inhibitor screening tool. This study demonstrates its performance by screening small molecules and neutralizing antibodies as potential inhibitors of the interaction between the spike protein 1 (S1) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the angiotensin-converting enzyme 2 (ACE2) receptor. The MMB-based assay is highly sensitive, has minimal non-specific binding, and is much faster than the commonly used ELISA (2 h vs. 7-24 h). We anticipate that our method will lead to a remarkable advance in screening for new drug candidates. Twit Text FOAVip Rapid and Sensitive Inhibitor Screening Using Magnetically Modulated Biosensors ????Sensors (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34300555 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34300555 #FOAvip English Wikipedia <ref>{{Cite pmid|34300555}}</ref> Rapid and Sensitive Inhibitor Screening Using Magnetically Modulated Biosensors #MMPMID34300555 Roth S; Danielli A Sensors (Basel) 2021[Jul]; 21 (14): ä PMID34300555show ga Inhibitor screening is an important tool for drug development, especially during the COVID-19 pandemic. The most used in vitro inhibitor screening tool is an enzyme-linked immunosorbent assay (ELISA). However, ELISA-based inhibitor screening is time consuming and has a limited dynamic range. Using fluorescently and magnetically modulated biosensors (MMB), we developed a rapid and sensitive inhibitor screening tool. This study demonstrates its performance by screening small molecules and neutralizing antibodies as potential inhibitors of the interaction between the spike protein 1 (S1) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the angiotensin-converting enzyme 2 (ACE2) receptor. The MMB-based assay is highly sensitive, has minimal non-specific binding, and is much faster than the commonly used ELISA (2 h vs. 7-24 h). We anticipate that our method will lead to a remarkable advance in screening for new drug candidates. |*Biosensing Techniques[MESH] |*COVID-19[MESH] |Humans[MESH] |Pandemics[MESH] |SARS-CoV-2[MESH]Rapid and Sensitive Inhibitor Screening Using Magnetically Modulated B(epmc).pdf DeepDyve Pubget Overpricing