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10.1089/vim.2021.0038 http://scihub22266oqcxt.onion/10.1089/vim.2021.0038 34297627!ä!34297627 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viral+Immunol 2021 ; 34 (9): 597-606 Nephropedia Template TP {{tp|p=34297627|t=2021. Pathogenesis of Coronaviruses Through Human Monocytes and Tissue Macrophages |pdf=|usr=}}{{34297627}} gab.com Text Pathogenesis of Coronaviruses Through Human Monocytes and Tissue Macrophages JO: Viral Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34297627 #FOAvip Coronaviruses (CoVs) contribute significantly to the burden of respiratory diseases, frequently as upper respiratory tract infections. Recent emergence of novel coronaviruses in the last few decades has highlighted the potential transmission, disease, and mortality related to these viruses. In this literature review, we shall explore the disease-causing mechanism of the virus through human monocytes and macrophages. Common strains will be discussed; however, this review will center around coronaviruses responsible for epidemics, namely severe acute respiratory syndrome coronavirus (SARS-CoV)-1 and -2 and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Macrophages are key players in the immune system and have been found to play a role in the pathogenesis of lethal coronaviruses. In physiology, they are white blood cells that engulf and digest cellular debris, foreign substances, and microbes. They play a critical role in innate immunity and help initiate adaptive immunity. Human coronaviruses utilize various mechanisms to undermine the innate immune response through its interaction with macrophages and monocytes. It is capable of entering immune cells through DPP4 (dipeptidyl-peptidase 4) receptors and antibody-dependent enhancement, delaying initial interferon response which supports robust viral replication. Pathogenesis includes triggering the production of overwhelming pro-inflammatory cytokines that attract other immune cells to the site of infection, which propagate prolonged pro-inflammatory response. The virus has also been found to suppress the release of anti-inflammatory mediators such as IL-10, leading to an aberrant inflammatory response. Elevated serum cytokines are also believed to contribute to pathological features seen in severe disease such as coagulopathy, acute lung injury, and multiorgan failure. Twit Text FOAVip Pathogenesis of Coronaviruses Through Human Monocytes and Tissue Macrophages ????Viral Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34297627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34297627 #FOAvip English Wikipedia <ref>{{Cite pmid|34297627}}</ref> Pathogenesis of Coronaviruses Through Human Monocytes and Tissue Macrophages #MMPMID34297627 Huang C Viral Immunol 2021[Nov]; 34 (9): 597-606 PMID34297627show ga Coronaviruses (CoVs) contribute significantly to the burden of respiratory diseases, frequently as upper respiratory tract infections. Recent emergence of novel coronaviruses in the last few decades has highlighted the potential transmission, disease, and mortality related to these viruses. In this literature review, we shall explore the disease-causing mechanism of the virus through human monocytes and macrophages. Common strains will be discussed; however, this review will center around coronaviruses responsible for epidemics, namely severe acute respiratory syndrome coronavirus (SARS-CoV)-1 and -2 and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Macrophages are key players in the immune system and have been found to play a role in the pathogenesis of lethal coronaviruses. In physiology, they are white blood cells that engulf and digest cellular debris, foreign substances, and microbes. They play a critical role in innate immunity and help initiate adaptive immunity. Human coronaviruses utilize various mechanisms to undermine the innate immune response through its interaction with macrophages and monocytes. It is capable of entering immune cells through DPP4 (dipeptidyl-peptidase 4) receptors and antibody-dependent enhancement, delaying initial interferon response which supports robust viral replication. Pathogenesis includes triggering the production of overwhelming pro-inflammatory cytokines that attract other immune cells to the site of infection, which propagate prolonged pro-inflammatory response. The virus has also been found to suppress the release of anti-inflammatory mediators such as IL-10, leading to an aberrant inflammatory response. Elevated serum cytokines are also believed to contribute to pathological features seen in severe disease such as coagulopathy, acute lung injury, and multiorgan failure. |*Immunity, Innate[MESH] |Animals[MESH] |Coronavirus Infections/*immunology/pathology/virology[MESH] |Coronavirus/classification/*immunology/*pathogenicity[MESH] |Cytokines/blood/immunology[MESH] |Humans[MESH] |Inflammation/immunology/virology[MESH] |Lung/pathology[MESH] |Macrophages/immunology/*virology[MESH] |Monocytes/immunology/*virology[MESH]Pathogenesis of Coronaviruses Through Human Monocytes and Tissue Macro(epmc).pdf DeepDyve Pubget Overpricing