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10.1021/acs.jcim.1c00642 http://scihub22266oqcxt.onion/10.1021/acs.jcim.1c00642 34297570!ä!34297570 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34297570&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Chem+Inf+Model 2021 ; 61 (8): 4058-4067 Nephropedia Template TP {{tp|p=34297570|t=2021. Knowledge Graph-Based Approaches to Drug Repurposing for COVID-19 |pdf=|usr=}}{{34297570}} gab.com Text Knowledge Graph-Based Approaches to Drug Repurposing for COVID-19 JO: J Chem Inf Model http://www.kidney.de/pget.php?&tw=1&pmid=34297570 #FOAvip The COVID-19 pandemic has motivated researchers all over the world in trying to find effective drugs and therapeutics for treating this disease. To save time, much effort has focused on repurposing drugs known for treating other diseases than COVID-19. To support these drug repurposing efforts, we built the CAS Biomedical Knowledge Graph and identified 1350 small molecules as potentially repurposable drugs that target host proteins and disease processes involved in COVID-19. A computer algorithm-driven drug-ranking method was developed to prioritize those identified small molecules. The top 50 molecules were analyzed according to their molecular functions and included 11 drugs in clinical trials for treating COVID-19 and new candidates that may be of interest for clinical investigation. The CAS Biomedical Knowledge Graph provides researchers an opportunity to accelerate innovation and streamline the investigative process not just for COVID-19 but also in many other diseases. Twit Text FOAVip Knowledge Graph-Based Approaches to Drug Repurposing for COVID-19 ????J Chem Inf Model http://www.kidney.de/pget.php?&tw=1&pmid=34297570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34297570 #FOAvip English Wikipedia <ref>{{Cite pmid|34297570}}</ref> Knowledge Graph-Based Approaches to Drug Repurposing for COVID-19 #MMPMID34297570 Al-Saleem J; Granet R; Ramakrishnan S; Ciancetta NA; Saveson C; Gessner C; Zhou Q J Chem Inf Model 2021[Aug]; 61 (8): 4058-4067 PMID34297570show ga The COVID-19 pandemic has motivated researchers all over the world in trying to find effective drugs and therapeutics for treating this disease. To save time, much effort has focused on repurposing drugs known for treating other diseases than COVID-19. To support these drug repurposing efforts, we built the CAS Biomedical Knowledge Graph and identified 1350 small molecules as potentially repurposable drugs that target host proteins and disease processes involved in COVID-19. A computer algorithm-driven drug-ranking method was developed to prioritize those identified small molecules. The top 50 molecules were analyzed according to their molecular functions and included 11 drugs in clinical trials for treating COVID-19 and new candidates that may be of interest for clinical investigation. The CAS Biomedical Knowledge Graph provides researchers an opportunity to accelerate innovation and streamline the investigative process not just for COVID-19 but also in many other diseases. |*COVID-19[MESH] |*Drug Repositioning[MESH] |Antiviral Agents[MESH] |Humans[MESH] |Pandemics[MESH] |Pattern Recognition, Automated[MESH]Knowledge Graph-Based Approaches to Drug Repurposing for COVID-19 (epmc).pdf DeepDyve Pubget Overpricing