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10.15252/embj.2021108249 http://scihub22266oqcxt.onion/10.15252/embj.2021108249 34296442!8420271!34296442     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2021 ; 40 (18): e108249 Nephropedia Template TP {{tp|p=34296442|t=2021. SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage |pdf=|usr=}}{{34296442}} gab.com Text SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=34296442 #FOAvip SARS-CoV-2 is an emerging coronavirus that causes dysfunctions in multiple human cells and tissues. Studies have looked at the entry of SARS-CoV-2 into host cells mediated by the viral spike protein and human receptor ACE2. However, less is known about the cellular immune responses triggered by SARS-CoV-2 viral proteins. Here, we show that the nucleocapsid of SARS-CoV-2 inhibits host pyroptosis by blocking Gasdermin D (GSDMD) cleavage. SARS-CoV-2-infected monocytes show enhanced cellular interleukin-1beta (IL-1beta) expression, but reduced IL-1beta secretion. While SARS-CoV-2 infection promotes activation of the NLRP3 inflammasome and caspase-1, GSDMD cleavage and pyroptosis are inhibited in infected human monocytes. SARS-CoV-2 nucleocapsid protein associates with GSDMD in cells and inhibits GSDMD cleavage in vitro and in vivo. The nucleocapsid binds the GSDMD linker region and hinders GSDMD processing by caspase-1. These insights into how SARS-CoV-2 antagonizes cellular inflammatory responses may open new avenues for treating COVID-19 in the future. Twit Text FOAVip SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=34296442 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34296442 #FOAvip English Wikipedia <ref>{{Cite pmid|34296442}}</ref> SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage #MMPMID34296442 Ma J; Zhu F; Zhao M; Shao F; Yu D; Ma J; Zhang X; Li W; Qian Y; Zhang Y; Jiang D; Wang S; Xia P EMBO J 2021[Sep]; 40 (18): e108249 PMID34296442show ga SARS-CoV-2 is an emerging coronavirus that causes dysfunctions in multiple human cells and tissues. Studies have looked at the entry of SARS-CoV-2 into host cells mediated by the viral spike protein and human receptor ACE2. However, less is known about the cellular immune responses triggered by SARS-CoV-2 viral proteins. Here, we show that the nucleocapsid of SARS-CoV-2 inhibits host pyroptosis by blocking Gasdermin D (GSDMD) cleavage. SARS-CoV-2-infected monocytes show enhanced cellular interleukin-1beta (IL-1beta) expression, but reduced IL-1beta secretion. While SARS-CoV-2 infection promotes activation of the NLRP3 inflammasome and caspase-1, GSDMD cleavage and pyroptosis are inhibited in infected human monocytes. SARS-CoV-2 nucleocapsid protein associates with GSDMD in cells and inhibits GSDMD cleavage in vitro and in vivo. The nucleocapsid binds the GSDMD linker region and hinders GSDMD processing by caspase-1. These insights into how SARS-CoV-2 antagonizes cellular inflammatory responses may open new avenues for treating COVID-19 in the future. |Angiotensin-Converting Enzyme 2/immunology/metabolism[MESH] |Animals[MESH] |COVID-19/immunology/*metabolism/pathology/virology[MESH] |Caspase 1/immunology/metabolism[MESH] |HEK293 Cells[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Inflammasomes/immunology/metabolism[MESH] |Interleukin-1beta/immunology/metabolism[MESH] |Intracellular Signaling Peptides and Proteins/immunology/*metabolism[MESH] |Mice[MESH] |Monocytes/metabolism[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/immunology/metabolism[MESH] |Nucleocapsid/*metabolism[MESH] |Phosphate-Binding Proteins/immunology/*metabolism[MESH] |Pyroptosis/*physiology[MESH] |SARS-CoV-2/immunology/*metabolism[MESH] |Spike Glycoprotein, Coronavirus/immunology/metabolism[MESH]SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasderm(epmc).pdf DeepDyve Pubget Overpricing