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10.1016/j.ijmmb.2021.07.003

http://scihub22266oqcxt.onion/10.1016/j.ijmmb.2021.07.003
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suck abstract from ncbi


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pmid34294504      Indian+J+Med+Microbiol 2021 ; 39 (4): 457-461
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  • Rapid antigen detection kit for the diagnosis of SARS-CoV-2 - are we missing asymptomatic patients? #MMPMID34294504
  • Kanaujia R; Ghosh A; Mohindra R; Singla V; Goyal K; Gudisa R; Sharma V; Mohan L; Kaur N; Mohi GK; Bora I; Ratho RK; Soni RK; Bhalla A; Singh MP
  • Indian J Med Microbiol 2021[Oct]; 39 (4): 457-461 PMID34294504show ga
  • PURPOSE: To determine the utility, diagnostic accuracy, sensitivity, specificity, and negative predictive value of the laboratory based Covid-19 antigen detection test (Coris Bio- Concept, Gembloux, Belgium) for the diagnosis of SARS-CoV-2 in a tertiary care hospital among symptomatic and asymptomatic patients. METHODS: The nasopharyngeal swab samples were collected from the symptomatic patients and their contacts. The diagnostic accuracy of this antigen kit was determined in comparison to SARS-CoV-2 real-time reverse transcriptase (RT-PCR). RESULTS: A total of 825 patients fulfilling the inclusion criteria were included in the study; RT-PCR and antigen detection was performed simultaneously for 484 samples to determine the sensitivity and specificity of the test. The overall specificity and sensitivity was 99.32% and 71.96% respectively. Also, 3.7% of the asymptomatic patients who were negative by RAT were detected positive by RT-PCR. CONCLUSION: This rapid antigen test (RAT) was sensitive in the symptomatic patients presenting during the initial phase of the illness. Since, majority of the SARS-CoV-2 patients are asymptomatic and considering the huge population, the testing strategy formulated by Indian Council of Medical Research (ICMR) at the national level was cost effective. Thus, Ag-RDTs could play a pivotal role in early diagnosis, policy making and surveillance of the SARS-CoV-2.
  • |*COVID-19/diagnosis[MESH]
  • |*SARS-CoV-2/isolation & purification[MESH]
  • |Antigens, Viral/*analysis[MESH]
  • |Asymptomatic Infections[MESH]
  • |COVID-19 Testing[MESH]
  • |Humans[MESH]
  • |Predictive Value of Tests[MESH]


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