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10.1073/pnas.2104241118 http://scihub22266oqcxt.onion/10.1073/pnas.2104241118 34292871!8307621!34292871     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2021 ; 118 (29): ä Nephropedia Template TP {{tp|p=34292871|t=2021. Ongoing global and regional adaptive evolution of SARS-CoV-2 |pdf=|usr=}}{{34292871}} gab.com Text Ongoing global and regional adaptive evolution of SARS-CoV-2 JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34292871 #FOAvip Understanding the trends in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution is paramount to control the COVID-19 pandemic. We analyzed more than 300,000 high-quality genome sequences of SARS-CoV-2 variants available as of January 2021. The results show that the ongoing evolution of SARS-CoV-2 during the pandemic is characterized primarily by purifying selection, but a small set of sites appear to evolve under positive selection. The receptor-binding domain of the spike protein and the region of the nucleocapsid protein associated with nuclear localization signals (NLS) are enriched with positively selected amino acid replacements. These replacements form a strongly connected network of apparent epistatic interactions and are signatures of major partitions in the SARS-CoV-2 phylogeny. Virus diversity within each geographic region has been steadily growing for the entirety of the pandemic, but analysis of the phylogenetic distances between pairs of regions reveals four distinct periods based on global partitioning of the tree and the emergence of key mutations. The initial period of rapid diversification into region-specific phylogenies that ended in February 2020 was followed by a major extinction event and global homogenization concomitant with the spread of D614G in the spike protein, ending in March 2020. The NLS-associated variants across multiple partitions rose to global prominence in March to July, during a period of stasis in terms of interregional diversity. Finally, beginning in July 2020, multiple mutations, some of which have since been demonstrated to enable antibody evasion, began to emerge associated with ongoing regional diversification, which might be indicative of speciation. Twit Text FOAVip Ongoing global and regional adaptive evolution of SARS-CoV-2 ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34292871 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34292871 #FOAvip English Wikipedia <ref>{{Cite pmid|34292871}}</ref> Ongoing global and regional adaptive evolution of SARS-CoV-2 #MMPMID34292871 Rochman ND; Wolf YI; Faure G; Mutz P; Zhang F; Koonin EV Proc Natl Acad Sci U S A 2021[Jul]; 118 (29): ä PMID34292871show ga Understanding the trends in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution is paramount to control the COVID-19 pandemic. We analyzed more than 300,000 high-quality genome sequences of SARS-CoV-2 variants available as of January 2021. The results show that the ongoing evolution of SARS-CoV-2 during the pandemic is characterized primarily by purifying selection, but a small set of sites appear to evolve under positive selection. The receptor-binding domain of the spike protein and the region of the nucleocapsid protein associated with nuclear localization signals (NLS) are enriched with positively selected amino acid replacements. These replacements form a strongly connected network of apparent epistatic interactions and are signatures of major partitions in the SARS-CoV-2 phylogeny. Virus diversity within each geographic region has been steadily growing for the entirety of the pandemic, but analysis of the phylogenetic distances between pairs of regions reveals four distinct periods based on global partitioning of the tree and the emergence of key mutations. The initial period of rapid diversification into region-specific phylogenies that ended in February 2020 was followed by a major extinction event and global homogenization concomitant with the spread of D614G in the spike protein, ending in March 2020. The NLS-associated variants across multiple partitions rose to global prominence in March to July, during a period of stasis in terms of interregional diversity. Finally, beginning in July 2020, multiple mutations, some of which have since been demonstrated to enable antibody evasion, began to emerge associated with ongoing regional diversification, which might be indicative of speciation. |*Evolution, Molecular[MESH] |Adaptation, Physiological/*genetics[MESH] |Amino Acid Substitution[MESH] |COVID-19 Testing[MESH] |COVID-19/diagnosis/epidemiology/prevention & control/virology[MESH] |Coronavirus Nucleocapsid Proteins/genetics[MESH] |Epistasis, Genetic[MESH] |Genome, Viral/genetics[MESH] |Humans[MESH] |Immune Evasion/genetics[MESH] |Mutation[MESH] |Nuclear Localization Signals/genetics[MESH] |Phosphoproteins/genetics[MESH] |Phylogeny[MESH] |Protein Interaction Domains and Motifs/genetics[MESH] |SARS-CoV-2/classification/*genetics[MESH] |Selection, Genetic[MESH] |Spike Glycoprotein, Coronavirus/genetics[MESH]Ongoing global and regional adaptive evolution of SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing