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10.1002/jmv.27225 http://scihub22266oqcxt.onion/10.1002/jmv.27225 34292617!8426869!34292617     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (12): 6595-6604 Nephropedia Template TP {{tp|p=34292617|t=2021. Evolution trace of SARS-CoV-2 from January 19 to March 12, 2020, in the United States |pdf=|usr=}}{{34292617}} gab.com Text Evolution trace of SARS-CoV-2 from January 19 to March 12, 2020, in the United States JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=34292617 #FOAvip As a kind of human betacoronavirus, SARS-CoV-2 has endangered globally public health. As of January 2021, the virus had resulted in 2,209,195 deaths. By studying the evolution trend and characteristics of 265 SARS-CoV-2 strains in the United States from January to March, it is found that the strains can be divided into six clades, USA clade-1, USA clade-2, USA clade-3, USA clade-4, USA clade-5, and USA clade-6, in which US clade-1 may be the most ancestral clade, USA clade-2 is an interim clade of USA clade-1 and USA clade-3, the other three clades have similar codon usage pattern, while USA clade-6 is the newest and most adaptable clade. Mismatch analysis and protein alignment showed that the evolution of the clades arises from some special mutations in viral proteins, which may help the strain to invade, replicate, transcribe and so on. Compared with previous research and classifications, we suggest that clade O in GISAID should not be an independent clade and Wuhan-Hu-1 (EPI_ISL_402125) should not be an ancestral reference sequence. Our study decoded the evolutionary dynamic of SARS-CoV-2 in the early stage from the United States, which give some clues to infer the current evolution trend of SARS-CoV-2 and study the function of viral mutational protein. Twit Text FOAVip Evolution trace of SARS-CoV-2 from January 19 to March 12, 2020, in the United States ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=34292617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34292617 #FOAvip English Wikipedia <ref>{{Cite pmid|34292617}}</ref> Evolution trace of SARS-CoV-2 from January 19 to March 12, 2020, in the United States #MMPMID34292617 Lin Z; Qing H; Li R; Zheng L; Yao H J Med Virol 2021[Dec]; 93 (12): 6595-6604 PMID34292617show ga As a kind of human betacoronavirus, SARS-CoV-2 has endangered globally public health. As of January 2021, the virus had resulted in 2,209,195 deaths. By studying the evolution trend and characteristics of 265 SARS-CoV-2 strains in the United States from January to March, it is found that the strains can be divided into six clades, USA clade-1, USA clade-2, USA clade-3, USA clade-4, USA clade-5, and USA clade-6, in which US clade-1 may be the most ancestral clade, USA clade-2 is an interim clade of USA clade-1 and USA clade-3, the other three clades have similar codon usage pattern, while USA clade-6 is the newest and most adaptable clade. Mismatch analysis and protein alignment showed that the evolution of the clades arises from some special mutations in viral proteins, which may help the strain to invade, replicate, transcribe and so on. Compared with previous research and classifications, we suggest that clade O in GISAID should not be an independent clade and Wuhan-Hu-1 (EPI_ISL_402125) should not be an ancestral reference sequence. Our study decoded the evolutionary dynamic of SARS-CoV-2 in the early stage from the United States, which give some clues to infer the current evolution trend of SARS-CoV-2 and study the function of viral mutational protein. |*Evolution, Molecular[MESH] |Bayes Theorem[MESH] |COVID-19/virology[MESH] |Humans[MESH] |Mutation/genetics[MESH] |Phylogeny[MESH] |Principal Component Analysis[MESH] |SARS-CoV-2/*genetics[MESH] |Sequence Alignment[MESH]Evolution trace of SARS-CoV-2 from January 19 to March 12, 2020, in th(epmc).pdf DeepDyve Pubget Overpricing