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10.1111/cup.14104

http://scihub22266oqcxt.onion/10.1111/cup.14104
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34292611!8444807!34292611
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suck abstract from ncbi


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pmid34292611      J+Cutan+Pathol 2022 ; 49 (1): 34-41
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  • Clinical and histopathological spectrum of delayed adverse cutaneous reactions following COVID-19 vaccination #MMPMID34292611
  • Larson V; Seidenberg R; Caplan A; Brinster NK; Meehan SA; Kim RH
  • J Cutan Pathol 2022[Jan]; 49 (1): 34-41 PMID34292611show ga
  • BACKGROUND: As more people become vaccinated against the SARS-CoV-2 virus, reports of delayed cutaneous hypersensitivity reactions are beginning to emerge. METHODS: In this IRB-approved retrospective case series, biopsy specimens of potential cutaneous adverse reactions from the Pfizer-BioNTech or Moderna mRNA vaccine were identified and reviewed. Clinical information was obtained through the requisition form, referring clinician, or medical chart review. RESULTS: Twelve cases were included. Histopathological features from two injection-site reactions showed a mixed-cell infiltrate with eosinophils and a spongiotic dermatitis with eosinophils. Three biopsy specimens came from generalized eruptions that showed interface changes consistent with an exanthematous drug reaction. Three biopsy specimens revealed a predominantly spongiotic pattern, consistent with eczematous dermatitis. Small-vessel vascular injury was seen in two specimens, which were diagnosed as urticarial vasculitis and leukocytoclastic vasculitis, respectively. There were two cases of new-onset bullous pemphigoid supported by histopathological examination and direct immunofluorescence studies. Eosinophils were seen in 10 cases. CONCLUSIONS: Dermatopathologists should be aware of potential cutaneous adverse reactions to mRNA-based COVID-19 vaccines. Histopathological patterns include mixed-cell infiltrates, epidermal spongiosis, and interface changes. Eosinophils are a common finding but are not always present. Direct immunofluorescence studies may be helpful for immune-mediated cutaneous presentations such as vasculitis or bullous pemphigoid.
  • |2019-nCoV Vaccine mRNA-1273/adverse effects[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |BNT162 Vaccine/adverse effects[MESH]
  • |Biopsy/methods[MESH]
  • |COVID-19 Vaccines/*adverse effects[MESH]
  • |COVID-19/diagnosis/immunology/*prevention & control/virology[MESH]
  • |Dermatitis/etiology/pathology[MESH]
  • |Drug-Related Side Effects and Adverse Reactions/etiology/*pathology[MESH]
  • |Eosinophils/pathology[MESH]
  • |Female[MESH]
  • |Fluorescent Antibody Technique, Direct/methods[MESH]
  • |Humans[MESH]
  • |Hypersensitivity, Delayed/etiology/*pathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pemphigoid, Bullous/diagnosis/pathology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/genetics/immunology[MESH]
  • |Skin/pathology[MESH]


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