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10.1021/jacs.1c04933

http://scihub22266oqcxt.onion/10.1021/jacs.1c04933
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34291944!ä!34291944

suck abstract from ncbi


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pmid34291944      J+Am+Chem+Soc 2021 ; 143 (31): 12194-12201
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  • ACE2 Receptor-Modified Algae-Based Microrobot for Removal of SARS-CoV-2 in Wastewater #MMPMID34291944
  • Zhang F; Li Z; Yin L; Zhang Q; Askarinam N; Mundaca-Uribe R; Tehrani F; Karshalev E; Gao W; Zhang L; Wang J
  • J Am Chem Soc 2021[Aug]; 143 (31): 12194-12201 PMID34291944show ga
  • The coronavirus SARS-CoV-2 can survive in wastewater for several days with a potential risk of waterborne human transmission, hence posing challenges in containing the virus and reducing its spread. Herein, we report on an active biohybrid microrobot system that offers highly efficient capture and removal of target virus from various aquatic media. The algae-based microrobot is fabricated by using click chemistry to functionalize microalgae with angiotensin-converting enzyme 2 (ACE2) receptor against the SARS-CoV-2 spike protein. The resulting ACE2-algae-robot displays fast (>100 mum/s) and long-lasting (>24 h) self-propulsion in diverse aquatic media including drinking water and river water, obviating the need for external fuels. Such movement of the ACE2-algae-robot offers effective "on-the-fly" removal of SARS-CoV-2 spike proteins and SARS-CoV-2 pseudovirus. Specifically, the active biohybrid microrobot results in 95% removal of viral spike protein and 89% removal of pseudovirus, significantly exceeding the control groups such as static ACE2-algae and bare algae. These results suggest considerable promise of biologically functionalized algae toward the removal of viruses and other environmental threats from wastewater.
  • |Angiotensin-Converting Enzyme 2/*chemistry/metabolism[MESH]
  • |Biotechnology/instrumentation/*methods[MESH]
  • |Cell Line[MESH]
  • |Click Chemistry[MESH]
  • |Humans[MESH]
  • |Microalgae/*chemistry[MESH]
  • |Receptors, Virus/chemistry/metabolism[MESH]
  • |SARS-CoV-2/*isolation & purification/metabolism[MESH]
  • |Wastewater/*virology[MESH]


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