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10.2217/fvl-2020-0361

http://scihub22266oqcxt.onion/10.2217/fvl-2020-0361
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34290823!8285112!34290823
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suck abstract from ncbi

pmid34290823      Future+Virol 2021 ; ? (?): ?
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  • Reappraisal of trifluperidol against Nsp3 as a potential therapeutic for novel COVID-19: a molecular docking and dynamics study #MMPMID34290823
  • Pandey A; Sharma M
  • Future Virol 2021[Jun]; ? (?): ? PMID34290823show ga
  • Novel COVID-19 is a highly infectious disease that is caused by the recently discovered SARS-CoV-2. It is a fast-spreading disease that urgently requires therapeutics. The current study employed computational regression methods to target the ADP-ribose phosphatase (ADRP) domain of Nsp3 using FDA-approved drugs. Identified leads were further investigated using molecular dynamics simulation (MDS). The screening and MDS results suggest that trifluperidol could be a novel inhibitor of the ADRP domain of Nsp3. Trifluperidol could, therefore, be used to help control the spread of COVID-19, either alone or in combination with antiviral agents.
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