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10.1038/s41423-021-00728-2 http://scihub22266oqcxt.onion/10.1038/s41423-021-00728-2 34290398!8294321!34290398     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Immunol 2021 ; 18 (9): 2128-2139 Nephropedia Template TP {{tp|p=34290398|t=2021. Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection |pdf=|usr=}}{{34290398}} gab.com Text Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34290398 #FOAvip Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-alpha). In COVID-19 there is a deficit in DC numbers and IFN-alpha production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin beta7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19. Twit Text FOAVip Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34290398 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34290398 #FOAvip English Wikipedia <ref>{{Cite pmid|34290398}}</ref> Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection #MMPMID34290398 Perez-Gomez A; Vitalle J; Gasca-Capote C; Gutierrez-Valencia A; Trujillo-Rodriguez M; Serna-Gallego A; Munoz-Muela E; Jimenez-Leon MLR; Rafii-El-Idrissi Benhnia M; Rivas-Jeremias I; Sotomayor C; Roca-Oporto C; Espinosa N; Infante-Dominguez C; Crespo-Rivas JC; Fernandez-Villar A; Perez-Gonzalez A; Lopez-Cortes LF; Poveda E; Ruiz-Mateos E Cell Mol Immunol 2021[Sep]; 18 (9): 2128-2139 PMID34290398show ga Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-alpha). In COVID-19 there is a deficit in DC numbers and IFN-alpha production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin beta7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19. |COVID-19/*immunology[MESH] |Cells, Cultured[MESH] |Dendritic Cells/*immunology[MESH] |Female[MESH] |Humans[MESH] |Immunity, Innate/immunology[MESH] |Inflammation/immunology[MESH] |Interferon-alpha/immunology[MESH] |Leukocytes, Mononuclear/immunology[MESH] |Male[MESH] |SARS-CoV-2/*immunology[MESH]Dendritic cell deficiencies persist seven months after SARS-CoV-2 infe(epmc).pdf DeepDyve Pubget Overpricing