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10.1038/s41598-021-94547-0

http://scihub22266oqcxt.onion/10.1038/s41598-021-94547-0
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34290378!8295385!34290378
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suck abstract from ncbi


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pmid34290378      Sci+Rep 2021 ; 11 (1): 14903
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  • Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2 #MMPMID34290378
  • Levy JM; Frediani JK; Tyburski EA; Wood A; Figueroa J; Kempker RR; Rebolledo PA; Gonzalez MD; Sullivan J; Vos MB; O'Neal J; Martin GS; Lam WA; Waggoner JJ
  • Sci Rep 2021[Jul]; 11 (1): 14903 PMID34290378show ga
  • The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74, 100% concordance) and antigen-based (n = 147, 97% concordance, kappa = 0.95, CI = 0.88-1.00) diagnostic assays. Repeated sample collection does not decrease COVID-19 test performance, demonstrating that multiple samples can be collected for assay validation and clinical diagnosis.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19 Testing/*methods[MESH]
  • |COVID-19/*diagnosis/*virology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Reproducibility of Results[MESH]
  • |SARS-CoV-2/*isolation & purification[MESH]
  • |Sensitivity and Specificity[MESH]
  • |Specimen Handling/*methods[MESH]


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