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10.1183/13993003.00284-2021 http://scihub22266oqcxt.onion/10.1183/13993003.00284-2021 34289974!8311281!34289974     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34289974.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+Respir+J 2022 ; 59 (2): ä Nephropedia Template TP {{tp|p=34289974|t=2022. Metabolomic analyses reveal new stage-specific features of COVID-19 |pdf=|usr=}}{{34289974}} gab.com Text Metabolomic analyses reveal new stage-specific features of COVID-19 JO: Eur Respir J http://www.kidney.de/pget.php?&tw=1&pmid=34289974 #FOAvip The current pandemic of coronavirus disease 2019 (COVID-19) has affected >160 million individuals to date, and has caused millions of deaths worldwide, at least in part due to the unclarified pathophysiology of this disease. Identifying the underlying molecular mechanisms of COVID-19 is critical to overcome this pandemic. Metabolites mirror the disease progression of an individual and can provide extensive insights into their pathophysiological significance at each stage of disease. We provide a comprehensive view of metabolic characterisation of sera from COVID-19 patients at all stages using untargeted and targeted metabolomic analysis. As compared with the healthy controls, we observed different alteration patterns of circulating metabolites from the mild, severe and recovery stages, in both the discovery cohort and the validation cohort, which suggests that metabolic reprogramming of glucose metabolism and the urea cycle are potential pathological mechanisms for COVID-19 progression. Our findings suggest that targeting glucose metabolism and the urea cycle may be a viable approach to fight COVID-19 at various stages along the disease course. Twit Text FOAVip Metabolomic analyses reveal new stage-specific features of COVID-19 ????Eur Respir J http://www.kidney.de/pget.php?&tw=1&pmid=34289974 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34289974 #FOAvip English Wikipedia <ref>{{Cite pmid|34289974}}</ref> Metabolomic analyses reveal new stage-specific features of COVID-19 #MMPMID34289974 Jia H; Liu C; Li D; Huang Q; Liu D; Zhang Y; Ye C; Zhou D; Wang Y; Tan Y; Li K; Lin F; Zhang H; Lin J; Xu Y; Liu J; Zeng Q; Hong J; Chen G; Zhang H; Zheng L; Deng X; Ke C; Gao Y; Fan J; Di B; Liang H Eur Respir J 2022[Feb]; 59 (2): ä PMID34289974show ga The current pandemic of coronavirus disease 2019 (COVID-19) has affected >160 million individuals to date, and has caused millions of deaths worldwide, at least in part due to the unclarified pathophysiology of this disease. Identifying the underlying molecular mechanisms of COVID-19 is critical to overcome this pandemic. Metabolites mirror the disease progression of an individual and can provide extensive insights into their pathophysiological significance at each stage of disease. We provide a comprehensive view of metabolic characterisation of sera from COVID-19 patients at all stages using untargeted and targeted metabolomic analysis. As compared with the healthy controls, we observed different alteration patterns of circulating metabolites from the mild, severe and recovery stages, in both the discovery cohort and the validation cohort, which suggests that metabolic reprogramming of glucose metabolism and the urea cycle are potential pathological mechanisms for COVID-19 progression. Our findings suggest that targeting glucose metabolism and the urea cycle may be a viable approach to fight COVID-19 at various stages along the disease course. |*COVID-19[MESH] |Cohort Studies[MESH] |Humans[MESH] |Metabolomics[MESH] |Pandemics[MESH]Metabolomic analyses reveal new stage-specific features of COVID-19 (epmc).pdf DeepDyve Pubget Overpricing