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10.1093/jmcb/mjab045 http://scihub22266oqcxt.onion/10.1093/jmcb/mjab045 34289053!8344946!34289053     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Cell+Biol 2021 ; 13 (10): 712-720 Nephropedia Template TP {{tp|p=34289053|t=2021. The virological impacts of SARS-CoV-2 D614G mutation |pdf=|usr=}}{{34289053}} gab.com Text The virological impacts of SARS-CoV-2 D614G mutation JO: J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34289053 #FOAvip The coronavirus diseases 2019 (COVID-19) caused by the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 has caused more than 140 million infections worldwide by the end of April 2021. As an enveloped single-stranded positive-sense RNA virus, SARS-CoV-2 underwent constant evolution that produced novel variants carrying mutation conferring fitness advantages. The current prevalent D614G variant, with glycine substituted for aspartic acid at position 614 in the spike glycoprotein, is one of such variants that became the main circulating strain worldwide in a short period of time. Over the past year, intensive studies from all over the world had defined the epidemiological characteristics of this highly contagious variant and revealed the underlying mechanisms. This review aims at presenting an overall picture of the impacts of D614G mutation on virus transmission, elucidating the underlying mechanisms of D614G in virus pathogenicity, and providing insights into the development of effective therapeutics. Twit Text FOAVip The virological impacts of SARS-CoV-2 D614G mutation ????J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34289053 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34289053 #FOAvip English Wikipedia <ref>{{Cite pmid|34289053}}</ref> The virological impacts of SARS-CoV-2 D614G mutation #MMPMID34289053 Wang C; Zheng Y; Niu Z; Jiang X; Sun Q J Mol Cell Biol 2021[Dec]; 13 (10): 712-720 PMID34289053show ga The coronavirus diseases 2019 (COVID-19) caused by the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 has caused more than 140 million infections worldwide by the end of April 2021. As an enveloped single-stranded positive-sense RNA virus, SARS-CoV-2 underwent constant evolution that produced novel variants carrying mutation conferring fitness advantages. The current prevalent D614G variant, with glycine substituted for aspartic acid at position 614 in the spike glycoprotein, is one of such variants that became the main circulating strain worldwide in a short period of time. Over the past year, intensive studies from all over the world had defined the epidemiological characteristics of this highly contagious variant and revealed the underlying mechanisms. This review aims at presenting an overall picture of the impacts of D614G mutation on virus transmission, elucidating the underlying mechanisms of D614G in virus pathogenicity, and providing insights into the development of effective therapeutics. |Amino Acid Substitution[MESH] |Aspartic Acid/genetics[MESH] |COVID-19/diagnosis/epidemiology/*transmission/virology[MESH] |Glycine/genetics[MESH] |Humans[MESH] |Molecular Epidemiology[MESH] |Mutation[MESH] |SARS-CoV-2/genetics/*pathogenicity[MESH] |Severity of Illness Index[MESH] |Spike Glycoprotein, Coronavirus/*genetics[MESH]The virological impacts of SARS-CoV-2 D614G mutation (epmc).pdf DeepDyve Pubget Overpricing