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10.1007/s11606-021-07017-8 http://scihub22266oqcxt.onion/10.1007/s11606-021-07017-8 34287774!8294343!34287774     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gen+Intern+Med 2021 ; 36 (11): 3478-3486 Nephropedia Template TP {{tp|p=34287774|t=2021. Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry |pdf=|usr=}}{{34287774}} gab.com Text Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry JO: J Gen Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=34287774 #FOAvip BACKGROUND: Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer (pDd) and dyspnea are common in both entities. OBJECTIVE: To determine the admission pDd cut-off value associated with in-hospital VTE in patients with COVID-19. METHODS: Multicenter, retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along hospitalization due to COVID-19. RESULTS: Among 9386 patients, 2.2% had VTE: 1.6% pulmonary embolism (PE), 0.4% deep vein thrombosis (DVT), and 0.2% both. Those with VTE had a higher prevalence of tachypnea (42.9% vs. 31.1%; p = 0.0005), basal O2 saturation <93% (45.4% vs. 33.1%; p = 0.0003), higher at admission pDd (median [IQR]: 1.4 [0.6-5.5] vs. 0.6 [0.4-1.2] mug/ml; p < 0.0001) and platelet count (median [IQR]: 208 [158-289] vs. 189 [148-245] platelets x 10(9)/L; p = 0.0013). A pDd cut-off of 1.1 mug/ml showed specificity 72%, sensitivity 49%, positive predictive value (PPV) 4%, and negative predictive value (NPV) 99% for in-hospital VTE. A cut-off value of 4.7 mug/ml showed specificity of 95%, sensitivity of 27%, PPV of 9%, and NPV of 98%. Overall mortality was proportional to pDd value, with the lowest incidence for each pDd category depending on anticoagulation intensity: 26.3% for those with pDd >1.0 mug/ml treated with prophylactic dose (p < 0.0001), 28.8% for pDd for patients with pDd >2.0 mug/ml treated with intermediate dose (p = 0.0001), and 31.3% for those with pDd >3.0 mug/ml and full anticoagulation (p = 0.0183). CONCLUSIONS: In hospitalized patients with COVID-19, a pDd value greater than 3.0 mug/ml can be considered to screen VTE and to consider full-dose anticoagulation. Twit Text FOAVip Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry ????J Gen Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=34287774 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34287774 #FOAvip English Wikipedia <ref>{{Cite pmid|34287774}}</ref> Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry #MMPMID34287774 Garcia-Cervera C; Giner-Galvan V; Wikman-Jorgensen P; Laureiro J; Rubio-Rivas M; Gurjian Arena A; Arnalich-Fernandez F; Beato Perez JL; Vargas Nunez JA; Gonzalez Igual JJ; Diez-Manglano J; Mendez Bailon M; Garcia Blanco MJ; Freire Castro SJ; Aranda Lobo J; Manzano L; Magallanes Gamboa JO; Arribas Perez L; Gonzalez Moraleja J; Calderon Hernaiz R; Garcia Alegria J; Gonzalez Noya A; Gomez Huelgas R; Lumbreras Bermejo C; Anton Santos JM J Gen Intern Med 2021[Nov]; 36 (11): 3478-3486 PMID34287774show ga BACKGROUND: Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer (pDd) and dyspnea are common in both entities. OBJECTIVE: To determine the admission pDd cut-off value associated with in-hospital VTE in patients with COVID-19. METHODS: Multicenter, retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along hospitalization due to COVID-19. RESULTS: Among 9386 patients, 2.2% had VTE: 1.6% pulmonary embolism (PE), 0.4% deep vein thrombosis (DVT), and 0.2% both. Those with VTE had a higher prevalence of tachypnea (42.9% vs. 31.1%; p = 0.0005), basal O2 saturation <93% (45.4% vs. 33.1%; p = 0.0003), higher at admission pDd (median [IQR]: 1.4 [0.6-5.5] vs. 0.6 [0.4-1.2] mug/ml; p < 0.0001) and platelet count (median [IQR]: 208 [158-289] vs. 189 [148-245] platelets x 10(9)/L; p = 0.0013). A pDd cut-off of 1.1 mug/ml showed specificity 72%, sensitivity 49%, positive predictive value (PPV) 4%, and negative predictive value (NPV) 99% for in-hospital VTE. A cut-off value of 4.7 mug/ml showed specificity of 95%, sensitivity of 27%, PPV of 9%, and NPV of 98%. Overall mortality was proportional to pDd value, with the lowest incidence for each pDd category depending on anticoagulation intensity: 26.3% for those with pDd >1.0 mug/ml treated with prophylactic dose (p < 0.0001), 28.8% for pDd for patients with pDd >2.0 mug/ml treated with intermediate dose (p = 0.0001), and 31.3% for those with pDd >3.0 mug/ml and full anticoagulation (p = 0.0183). CONCLUSIONS: In hospitalized patients with COVID-19, a pDd value greater than 3.0 mug/ml can be considered to screen VTE and to consider full-dose anticoagulation. |*COVID-19[MESH] |*Venous Thromboembolism/diagnosis/epidemiology[MESH] |*Venous Thrombosis/diagnosis/epidemiology[MESH] |Fibrin Fibrinogen Degradation Products[MESH] |Hospitalization[MESH] |Humans[MESH] |Registries[MESH] |Retrospective Studies[MESH]Estimation of Admission D-dimer Cut-off Value to Predict Venous Thromb(epmc).pdf DeepDyve Pubget Overpricing