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10.26355/eurrev_202107_26257 http://scihub22266oqcxt.onion/10.26355/eurrev_202107_26257 34286505!ä!34286505 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Rev+Med+Pharmacol+Sci 2021 ; 25 (13): 4639-4643 Nephropedia Template TP {{tp|p=34286505|t=2021. Immunohistochemical findings in the lungs of COVID-19 subjects: evidence of surfactant dysregulation |pdf=|usr=}}{{34286505}} gab.com Text Immunohistochemical findings in the lungs of COVID-19 subjects: evidence of surfactant dysregulation JO: Eur Rev Med Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34286505 #FOAvip OBJECTIVE: Acute respiratory distress syndrome (ARDS) is characterized by quantitative and qualitative changes in surfactant composition, leading to surfactant dysregulation with alveolar collapse and acute respiratory hypoxic failure. Recently, surfactant has been hypothesized to play a relevant role in COVID-19, representing a strong defender against SARS-CoV-2 infection. The aim of our work was the study of immunohistochemical surfactant expression in the lungs of patients died following SARS-CoV-2 ARDS, in order to shed light on a possible therapeutic surfactant administration. PATIENTS AND METHODS: We investigated four patients who died due to ARDS following SARS-COV-2 infection and four patients submitted to lung biopsy, in the absence of SARS-CoV-2 infection. In all 8 cases, lung specimens were immunostained with anti-surfactant protein A (SP-A) and B (SP-B). RESULTS: In control subjects, reactivity for SP-B was restricted to type II alveolar cells. Immunostaining for SP-A was observed on the surface of alveolar spaces. In the COVID-19 positive lungs, immunoreactivity for SP-B was similar to that observed in control lungs; SP-A was strongly expressed along the alveolar wall. Moreover, dense aggregates of SP-A positive material were observed in the alveolar spaces. CONCLUSIONS: Our immunohistochemical data show the dysregulation of surfactant production in COVID-19 patients, particularly regarding SP-A expression. The increased presence of SP-A in condensed masses inside alveolar spaces could invalidate the therapeutic efficacy of the treatment with exogenous surfactant. Twit Text FOAVip Immunohistochemical findings in the lungs of COVID-19 subjects: evidence of surfactant dysregulation ????Eur Rev Med Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34286505 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34286505 #FOAvip English Wikipedia <ref>{{Cite pmid|34286505}}</ref> Immunohistochemical findings in the lungs of COVID-19 subjects: evidence of surfactant dysregulation #MMPMID34286505 Gerosa C; Fanni D; Cau F; Ravarino A; Senes G; Demontis R; Coni P; Piras M; Orru G; Coghe F; Congiu T; La Nasa G; D'Aloja E; Saba L; Faa G Eur Rev Med Pharmacol Sci 2021[Jul]; 25 (13): 4639-4643 PMID34286505show ga OBJECTIVE: Acute respiratory distress syndrome (ARDS) is characterized by quantitative and qualitative changes in surfactant composition, leading to surfactant dysregulation with alveolar collapse and acute respiratory hypoxic failure. Recently, surfactant has been hypothesized to play a relevant role in COVID-19, representing a strong defender against SARS-CoV-2 infection. The aim of our work was the study of immunohistochemical surfactant expression in the lungs of patients died following SARS-CoV-2 ARDS, in order to shed light on a possible therapeutic surfactant administration. PATIENTS AND METHODS: We investigated four patients who died due to ARDS following SARS-COV-2 infection and four patients submitted to lung biopsy, in the absence of SARS-CoV-2 infection. In all 8 cases, lung specimens were immunostained with anti-surfactant protein A (SP-A) and B (SP-B). RESULTS: In control subjects, reactivity for SP-B was restricted to type II alveolar cells. Immunostaining for SP-A was observed on the surface of alveolar spaces. In the COVID-19 positive lungs, immunoreactivity for SP-B was similar to that observed in control lungs; SP-A was strongly expressed along the alveolar wall. Moreover, dense aggregates of SP-A positive material were observed in the alveolar spaces. CONCLUSIONS: Our immunohistochemical data show the dysregulation of surfactant production in COVID-19 patients, particularly regarding SP-A expression. The increased presence of SP-A in condensed masses inside alveolar spaces could invalidate the therapeutic efficacy of the treatment with exogenous surfactant. |*Immunohistochemistry[MESH] |COVID-19/diagnostic imaging/*metabolism[MESH] |Humans[MESH] |Protein Precursors/*analysis/genetics/metabolism[MESH] |Pulmonary Alveoli/diagnostic imaging/metabolism[MESH] |Pulmonary Surfactant-Associated Protein A/*analysis/genetics/metabolism[MESH] |Pulmonary Surfactant-Associated Proteins/*analysis/genetics/metabolism[MESH] |Retrospective Studies[MESH]Immunohistochemical findings in the lungs of COVID-19 subjects: eviden(epmc).pdf DeepDyve Pubget Overpricing